Genome-wide analysis of monocytes and T cells' response to interferon beta-GSE34627
To characterized the IFN-? transcriptional response in monocytes, a small but influential cell-subset, using gene expression profile and pathway analysis.
The unique expression profile of monocytes in response to Interferon-beta (IFN-?) might be masked by the response profile of the more abundant T cells.
Monocytes and T lymphocytes were isolated from 3 healthy volunteers. For each sample the expression profile of untreated cells was compared to the profile of IFN-? treated cells, i.e. 4 samples from each donor (2 cell types, with and without treatment), 12 samples total.
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| Sample ID | !Sample_title | donor | cell type | Culture conditions | treated |
|---|---|---|---|---|---|
| GSM852149 | T lymphocytes not treated with IFN-β, individual 1 | Individual1 | T lymphocytes | T cell_control | No |
| GSM852150 | T lymphocytes treated with IFN-β, individual 1 | Individual1 | T lymphocytes | T cell+IFNb | Yes |
| GSM852151 | Monocytes not treated with IFN-β, individual 1 | Individual1 | Monocytes | Mono_control | No |
| GSM852152 | Monocytes treated with IFN-β, individual 1 | Individual1 | Monocytes | Mono+IFNb | Yes |
| GSM852153 | T lymphocytes not treated with IFN-β, individual 2 | Individual2 | T lymphocytes | T cell_control | No |
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| Sample ID | !Sample Title | Donor | Cell type | Culture conditions | Treated |
|---|---|---|---|---|---|
| GSM852149 | T lymphocytes not treated with IFN-β, individual 1 |
Individual1 |
T lymphocytes |
T cell_control |
No |
| GSM852150 | T lymphocytes treated with IFN-β, individual 1 |
Individual1 |
T lymphocytes |
T cell+IFNb |
Yes |
| GSM852151 | Monocytes not treated with IFN-β, individual 1 |
Individual1 |
Monocytes |
Mono_control |
No |
| GSM852152 | Monocytes treated with IFN-β, individual 1 |
Individual1 |
Monocytes |
Mono+IFNb |
Yes |
| GSM852153 | T lymphocytes not treated with IFN-β, individual 2 |
Individual2 |
T lymphocytes |
T cell_control |
No |
| GSM852154 | T lymphocytes treated with IFN-β, individual 2 |
Individual2 |
T lymphocytes |
T cell+IFNb |
Yes |
| GSM852155 | Monocytes not treated with IFN-β, individual 2 |
Individual2 |
Monocytes |
Mono_control |
No |
| GSM852156 | Monocytes treated with IFN-β, individual 2 |
Individual2 |
Monocytes |
Mono+IFNb |
Yes |
| GSM852157 | T lymphocytes not treated with IFN-β, individual 3 |
Individual3 |
T lymphocytes |
T cell_control |
No |
| GSM852158 | T lymphocytes treated with IFN-β, individual 3 |
Individual3 |
T lymphocytes |
T cell+IFNb |
Yes |
| GSM852159 | Monocytes not treated with IFN-β, individual 3 |
Individual3 |
Monocytes |
Mono_control |
No |
| GSM852160 | Monocytes treated with IFN-β, individual 3 |
Individual3 |
Monocytes |
Mono+IFNb |
Yes |
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|---|---|---|
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