Monocyte gene expression profiling in familial combined hyperlipidemia and its modification by atorvastatin treatment-GSE11393
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Peripheral blood monocytes were isolated from male FCH patients basally and after 4 weeks of atorvastatin treatment. Sex-, age- and adiposity-matched controls were also studied. Gene expression profile was analyzed using Affymetrix Human Genome U133A 2.0 GeneChip arrays (3 replicates for each condition)
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Fasting plasma for determination of lipid profiles, inflammatory molecules, and adipokines was obtained and peripheral blood monocytes were isolated from male FCH patients basally and after 4 weeks of atorvastatin treatment. Sex-, age- and adiposity-matched controls were also studied. Gene expression profile was analyzed using Affymetrix Human Genome U133A 2.0 GeneChip arrays.
| Sample ID | !Sample_title | Human male subjects with familial combined hyperlipidemia after treatment with atorvastatin (ATV), peripheral blood monocytes | Human male subjects with familial combined hyperlipidemia (FCH), peripheral blood monocytes | Human healthy male subjects, peripheral blood monocytes | Sample grouping |
|---|---|---|---|---|---|
| GSM287664 | Monocyte control rep 1 | True | Healthy | ||
| GSM287665 | Monocyte control rep 2 | True | Healthy | ||
| GSM287666 | Monocyte control rep 3 | True | Healthy | ||
| GSM287667 | Monocyte FCH rep 1 | True | FCH | ||
| GSM287668 | Monocyte FCH rep 2 | True | FCH |
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| Sample ID | !Sample Title | Human male subjects with familial combined hyperlipidemia after treatment with atorvastatin (ATV), peripheral blood monocytes | Human male subjects with familial combined hyperlipidemia (FCH), peripheral blood monocytes | Human healthy male subjects, peripheral blood monocytes | Sample grouping |
|---|---|---|---|---|---|
| GSM287664 | Monocyte control rep 1 |
True |
Healthy |
||
| GSM287665 | Monocyte control rep 2 |
True |
Healthy |
||
| GSM287666 | Monocyte control rep 3 |
True |
Healthy |
||
| GSM287667 | Monocyte FCH rep 1 |
True |
FCH |
||
| GSM287668 | Monocyte FCH rep 2 |
True |
FCH |
||
| GSM287669 | Monocyte FCH rep 3 |
True |
FCH |
||
| GSM287670 | Monocyte ATV rep 1 |
True |
FCH-Post ATV |
||
| GSM287671 | Monocyte ATV rep 2 |
True |
FCH-Post ATV |
||
| GSM287672 | Monocyte ATV rep 3 |
True |
FCH-Post ATV |
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