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SIDRA

GXB

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Description

Monocyte gene expression profiling in familial combined hyperlipidemia and its modification by atorvastatin treatment-GSE11393

Experimental Design

Peripheral blood monocytes were isolated from male FCH patients basally and after 4 weeks of atorvastatin treatment. Sex-, age- and adiposity-matched controls were also studied. Gene expression profile was analyzed using Affymetrix Human Genome U133A 2.0 GeneChip arrays (3 replicates for each condition)

Methods

Fasting plasma for determination of lipid profiles, inflammatory molecules, and adipokines was obtained and peripheral blood monocytes were isolated from male FCH patients basally and after 4 weeks of atorvastatin treatment. Sex-, age- and adiposity-matched controls were also studied. Gene expression profile was analyzed using Affymetrix Human Genome U133A 2.0 GeneChip arrays.

Additional Information
  • Llaverias G, Pou J, Ros E, Zambón D et al. Monocyte gene-expression profile in men with familial combined hyperlipidemia and its modification by atorvastatin treatment. Pharmacogenomics 2008 Aug;9(8):1035-54. PMID: 18681780
  • Platform Affymetrix HG-U133A
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