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Clinical

Monocyte gene expression profiling in familial combined hyperlipidemia and its modification by atorvastatin treatment-GSE11393

Purpose

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Hypothesis

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Experimental Design

Peripheral blood monocytes were isolated from male FCH patients basally and after 4 weeks of atorvastatin treatment. Sex-, age- and adiposity-matched controls were also studied. Gene expression profile was analyzed using Affymetrix Human Genome U133A 2.0 GeneChip arrays (3 replicates for each condition)

Experimental Variables

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Controls

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Methods

Fasting plasma for determination of lipid profiles, inflammatory molecules, and adipokines was obtained and peripheral blood monocytes were isolated from male FCH patients basally and after 4 weeks of atorvastatin treatment. Sex-, age- and adiposity-matched controls were also studied. Gene expression profile was analyzed using Affymetrix Human Genome U133A 2.0 GeneChip arrays.

Additional Information
  • Llaverias G, Pou J, Ros E, Zambón D et al. Monocyte gene-expression profile in men with familial combined hyperlipidemia and its modification by atorvastatin treatment. Pharmacogenomics 2008 Aug;9(8):1035-54. PMID: 18681780
  • Microarray
    Affymetrix HG-U133A
    9 Samples Loaded: 9
    Human (Homo sapiens)
    Monocytes
    Familial combined hyperlipidemia
    Sample Set Spreadsheet
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    Samples Preview
    Sample ID !Sample_title Human male subjects with familial combined hyperlipidemia after treatment with atorvastatin (ATV), peripheral blood monocytes Human male subjects with familial combined hyperlipidemia (FCH), peripheral blood monocytes Human healthy male subjects, peripheral blood monocytes Sample grouping
    GSM287664 Monocyte control rep 1 True Healthy
    GSM287665 Monocyte control rep 2 True Healthy
    GSM287666 Monocyte control rep 3 True Healthy
    GSM287667 Monocyte FCH rep 1 True FCH
    GSM287668 Monocyte FCH rep 2 True FCH
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    File
    sampleset4000086_sampleannotations.csv
    Sample Set Spreadsheet
    Log2 Transformed
    Raw Signal
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    Sample ID !Sample Title Human male subjects with familial combined hyperlipidemia after treatment with atorvastatin (ATV), peripheral blood monocytes Human male subjects with familial combined hyperlipidemia (FCH), peripheral blood monocytes Human healthy male subjects, peripheral blood monocytes Sample grouping
    GSM287664
    Monocyte control rep 1
     
     
    True
    Healthy
    GSM287665
    Monocyte control rep 2
     
     
    True
    Healthy
    GSM287666
    Monocyte control rep 3
     
     
    True
    Healthy
    GSM287667
    Monocyte FCH rep 1
     
    True
     
    FCH
    GSM287668
    Monocyte FCH rep 2
     
    True
     
    FCH
    GSM287669
    Monocyte FCH rep 3
     
    True
     
    FCH
    GSM287670
    Monocyte ATV rep 1
    True
     
     
    FCH-Post ATV
    GSM287671
    Monocyte ATV rep 2
    True
     
     
    FCH-Post ATV
    GSM287672
    Monocyte ATV rep 3
    True
     
     
    FCH-Post ATV

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