TRAIL Is a Novel Antiviral Protein against Dengue Virus-GSE9378
To shed light on mechanisms involved in the cellular response to dengue virus (DV), we assessed gene expression changes, using Affymetrix GeneChips (HG-U133A), of infected primary human cells and identified changes common to all cells.
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For three human cell types, RNA was extracted and hybridized on Affymetrix microarrays. We compared a total of 10 samples. Five were infected in vitro for 48 hours with DV, including HUVECs (n=2), monocytes (n=2), and B-cells (n=1). Five were mock-infected controls of the same cell types and numbers. From these samples, were identified 23 genes that were induced by DV infection in all of the cell types.
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We used Affymetrix microarrays to study the response of human host cells to dengue virus (DV).
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Sample ID | !Sample_title | Genotype | Age | Cell type |
---|---|---|---|---|
GSM254447 | HUVEC control, biological rep1 | unknown | unknown | HUVEC |
GSM254448 | HUVEC control, biological rep2 | unknown | unknown | HUVEC |
GSM254449 | HUVEC infected, technical rep1 | unknown | unknown | HUVEC |
GSM254450 | HUVEC infected, technical rep2 | unknown | unknown | HUVEC |
GSM254451 | Monocyte control, biological rep1 | unknown | unknown | Monocyte |
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Sample ID | !Sample Title | Genotype | Age | Cell type |
---|---|---|---|---|
GSM254447 | HUVEC control, biological rep1 |
unknown |
unknown |
HUVEC |
GSM254448 | HUVEC control, biological rep2 |
unknown |
unknown |
HUVEC |
GSM254449 | HUVEC infected, technical rep1 |
unknown |
unknown |
HUVEC |
GSM254450 | HUVEC infected, technical rep2 |
unknown |
unknown |
HUVEC |
GSM254451 | Monocyte control, biological rep1 |
unknown |
unknown |
Monocyte |
GSM254452 | Monocyte control, biological rep2 |
unknown |
unknown |
Monocyte |
GSM254453 | Monocyte infected, biological rep1 |
unknown |
unknown |
Monocyte |
GSM254454 | Monocyte infected, biological rep2 |
unknown |
unknown |
Monocyte |
GSM254455 | B-cells control |
unknown |
unknown |
B cell |
GSM254456 | B-cells infected |
unknown |
unknown |
B cell |
Name | ||
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