Description | TRAIL Is a Novel Antiviral Protein against Dengue Virus-GSE9378 |
Purpose | To shed light on mechanisms involved in the cellular response to dengue virus (DV), we assessed gene expression changes, using Affymetrix GeneChips (HG-U133A), of infected primary human cells and identified changes common to all cells. |
Experimental Design | For three human cell types, RNA was extracted and hybridized on Affymetrix microarrays. We compared a total of 10 samples. Five were infected in vitro for 48 hours with DV, including HUVECs (n=2), monocytes (n=2), and B-cells (n=1). Five were mock-infected controls of the same cell types and numbers. From these samples, were identified 23 genes that were induced by DV infection in all of the cell types. |
Methods | We used Affymetrix microarrays to study the response of human host cells to dengue virus (DV). |
Platform | Affymetrix HG-U133A |
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