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Clinical

TRAIL Is a Novel Antiviral Protein against Dengue Virus-GSE9378

Purpose

To shed light on mechanisms involved in the cellular response to dengue virus (DV), we assessed gene expression changes, using Affymetrix GeneChips (HG-U133A), of infected primary human cells and identified changes common to all cells.

Hypothesis

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Experimental Design

For three human cell types, RNA was extracted and hybridized on Affymetrix microarrays. We compared a total of 10 samples. Five were infected in vitro for 48 hours with DV, including HUVECs (n=2), monocytes (n=2), and B-cells (n=1). Five were mock-infected controls of the same cell types and numbers. From these samples, were identified 23 genes that were induced by DV infection in all of the cell types.

Experimental Variables

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Controls

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Methods

We used Affymetrix microarrays to study the response of human host cells to dengue virus (DV).

Additional Information

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Microarray
Affymetrix HG-U133A
10 Samples Loaded: 10
Human (Homo sapiens)
Monocytes , Human umbilical vein endothelial cells , B cells
Dengue
Sample Set Spreadsheet
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Samples Preview
Sample ID !Sample_title Genotype Age Cell type
GSM254447 HUVEC control, biological rep1 unknown unknown HUVEC
GSM254448 HUVEC control, biological rep2 unknown unknown HUVEC
GSM254449 HUVEC infected, technical rep1 unknown unknown HUVEC
GSM254450 HUVEC infected, technical rep2 unknown unknown HUVEC
GSM254451 Monocyte control, biological rep1 unknown unknown Monocyte
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File
sampleset4000010_sampleannotations.csv
Sample Set Spreadsheet
Raw Signal
Raw Signal
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Clinical Datasource
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Samples Viewer / Editor

All fields are editable except the "Sample ID" column. To edit a cell, click within the cell. To edit a "date" cell, click on the calendar icon. To cancel an edit, press the ESC key.

Sample ID !Sample Title Genotype Age Cell type
GSM254447
HUVEC control, biological rep1
unknown
unknown
HUVEC
GSM254448
HUVEC control, biological rep2
unknown
unknown
HUVEC
GSM254449
HUVEC infected, technical rep1
unknown
unknown
HUVEC
GSM254450
HUVEC infected, technical rep2
unknown
unknown
HUVEC
GSM254451
Monocyte control, biological rep1
unknown
unknown
Monocyte
GSM254452
Monocyte control, biological rep2
unknown
unknown
Monocyte
GSM254453
Monocyte infected, biological rep1
unknown
unknown
Monocyte
GSM254454
Monocyte infected, biological rep2
unknown
unknown
Monocyte
GSM254455
B-cells control
unknown
unknown
B cell
GSM254456
B-cells infected
unknown
unknown
B cell

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Module Analysis

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