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Clinical

Bacillus anthracis' lethal toxin induces broad transcriptional responses in human peripheral monocyte-GSE34407

Purpose

Anthrax lethal toxin directly targets human peripheral monocytes and causes multiple aberrant gene responses that would be expected to result in defects in human monocyte’s normal signaling transduction pathways and nction. This study provides further insights into the mechanisms associated with the host immune system collapse during an anthrax infection, and suggests that anthrax LT may have additional targets outside the well-known MAPK pathway.

Hypothesis

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Experimental Design

There were 4 replicates, 1 control and 1 toxin treated from 4 donors, with 8 samples total.

Experimental Variables

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Controls

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Methods

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Additional Information
  • Chauncey KM, Lopez MC, Sidhu G, Szarowicz SE et al. Bacillus anthracis' lethal toxin induces broad transcriptional responses in human peripheral monocytes.BMC Immunol 2012 Jul 2;13:33. PMID: 22747600
  • Microarray
    Affymetrix HG-U133_Plus_2
    8 Samples Loaded: 8
    Human (Homo sapiens)
    Monocytes
    Healthy
    Sample Set Spreadsheet
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    Samples Preview
    Sample ID Age Gender !Sample_title cell type tissue
    GSM848717 52 year-old male Control_r1 monocytes whole blood
    GSM848718 52 year-old male Toxin_r1 monocytes whole blood
    GSM848719 24 year-old female Control_r2 monocytes whole blood
    GSM848720 24 year-old female Toxin_r2 monocytes whole blood
    GSM848721 31 year-old male Control_r3 monocytes whole blood
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    File
    sampleset4000119_sampleannotations.csv
    Sample Set Spreadsheet
    Raw Signal
    Raw Signal
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    Sample ID Age Gender !Sample Title Cell type Tissue Volunteer group Culture condition
    GSM848717
    52 year-old
    male
    Control_r1
    monocytes
    whole blood
    group1
    Control
    GSM848718
    52 year-old
    male
    Toxin_r1
    monocytes
    whole blood
    group1
    Toxin
    GSM848719
    24 year-old
    female
    Control_r2
    monocytes
    whole blood
    group2
    Control
    GSM848720
    24 year-old
    female
    Toxin_r2
    monocytes
    whole blood
    group2
    Toxin
    GSM848721
    31 year-old
    male
    Control_r3
    monocytes
    whole blood
    group3
    Control
    GSM848722
    31 year-old
    male
    Toxin_r3
    monocytes
    whole blood
    group3
    Toxin
    GSM848723
    36 year-old
    male
    Control_r4
    monocytes
    whole blood
    group4
    Control
    GSM848724
    36 year-old
    male
    Toxin_r4
    monocytes
    whole blood
    group4
    Toxin

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