Peripheral Blood Monocyte Gene Expression in Recent-Onset Type 1 Diabetes-GSE33440
Novel biomarkers of disease progression after type 1 diabetes onset are needed.
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CD14+ monocytes from a total of 16 children with recent-onset type 1 diabetes and 6 adult healthy controls were profiled in 2 independent microarrays.
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We profiled peripheral blood (PB) monocyte gene expression in 6 healthy subjects and 16 children with type 1 diabetes diagnosed ~3 months previously, and analyzed clinical features from diagnosis to 1 year.
| Sample ID | Gender | !Sample_title | hba1c 3months post diagnosis | hba1c 12months post diagnosis | age at diagnosis |
|---|---|---|---|---|---|
| GSM826974 | M | Array1_Healthy1 | not applicable | not applicable | adult |
| GSM826975 | M | Array1_Healthy2 | not applicable | not applicable | adult |
| GSM826976 | M | Array1_Diabetes1 | 6.4 | 6.9 | 9.28219178082192 |
| GSM826977 | F | Array1_Diabetes2 | 6.1 | 7.9 | 14.6438356164384 |
| GSM826978 | M | Array1_Diabetes3 | 6.4 | 7.4 | 12.6191780821918 |
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| Sample ID | Gender | !Sample Title | Hba1c 3months post diagnosis | Hba1c 12months post diagnosis | Age at diagnosis | Insulin dose (u/kg/day) 12months post diagnosis | Insulin dose (u/kg/day) 9months post diagnosis | Insulin dose (u/kg/day) 6months post diagnosis | Group | Hba1c 9months post diagnosis | Hba1c 6months post diagnosis | Insulin dose (u/kg/day) 3months post diagnosis | Array |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| GSM826974 | M |
Array1_Healthy1 |
not applicable |
not applicable |
adult |
not applicable |
not applicable |
not applicable |
Healthy |
not applicable |
not applicable |
not applicable |
Array1 |
| GSM826975 | M |
Array1_Healthy2 |
not applicable |
not applicable |
adult |
not applicable |
not applicable |
not applicable |
Healthy |
not applicable |
not applicable |
not applicable |
Array1 |
| GSM826976 | M |
Array1_Diabetes1 |
6.4 |
6.9 |
9.28219178082192 |
not available |
0.76 |
0.51 |
Diabetes Group A |
7.5 |
7.1 |
0.48 |
Array1 |
| GSM826977 | F |
Array1_Diabetes2 |
6.1 |
7.9 |
14.6438356164384 |
0.94 |
0.56 |
0.56 |
Diabetes Group A |
8.8 |
5.8 |
0.566893424036281 |
Array1 |
| GSM826978 | M |
Array1_Diabetes3 |
6.4 |
7.4 |
12.6191780821918 |
0.98 |
0.74 |
no visit |
Diabetes Group A |
6.4 |
no visit |
0.4 |
Array1 |
| GSM826979 | M |
Array1_Diabetes4 |
7.5 |
7.6 |
11.9835616438356 |
0.57 |
0.35 |
0.24 |
Diabetes Group B |
7.4 |
6.9 |
0.35 |
Array1 |
| GSM826980 | F |
Array1_Diabetes5 |
7 |
12.6 |
14.1178082191781 |
not available |
not available |
no visit |
Diabetes Group A |
14 |
no visit |
0.919117647058824 |
Array1 |
| GSM826981 | M |
Array1_Diabetes6 |
9.1 |
8.3 |
12.227397260274 |
1.19 |
1.07 |
0.886243386243386 |
Diabetes Group B |
8.2 |
9 |
0.72632944228275 |
Array1 |
| GSM826982 | F |
Array1_Diabetes7 |
7.3 |
7.5 |
8.65479452054795 |
0.8 |
0.9 |
0.547112462006079 |
Diabetes Group A |
7.6 |
7.3 |
0.547112462006079 |
Array1 |
| GSM826983 | F |
Array1_Diabetes8 |
6.9 |
8.9 |
11.0876712328767 |
1.15 |
no visit |
0.537190082644628 |
Diabetes Group B |
no visit |
7.3 |
0.521739130434783 |
Array1 |
| GSM826984 | M |
Array2_Healthy1 |
not applicable |
not applicable |
adult |
not applicable |
not applicable |
not applicable |
Healthy |
not applicable |
not applicable |
not applicable |
Array2 |
| GSM826985 | F |
Array2_Healthy2 |
not applicable |
not applicable |
adult |
not applicable |
not applicable |
not applicable |
Healthy |
not applicable |
not applicable |
not applicable |
Array2 |
| GSM826986 | M |
Array2_Healthy3 |
not applicable |
not applicable |
adult |
not applicable |
not applicable |
not applicable |
Healthy |
not applicable |
not applicable |
not applicable |
Array2 |
| GSM826987 | F |
Array2_Healthy4 |
not applicable |
not applicable |
adult |
not applicable |
not applicable |
not applicable |
Healthy |
not applicable |
not applicable |
not applicable |
Array2 |
| GSM826988 | F |
Array2_Diabetes1 |
8.4 |
8.1 |
9.24383561643836 |
not available |
Diabetes Group B |
7.5 |
7.7 |
0.41 |
Array2 |
||
| GSM826989 | F |
Array2_Diabetes2 |
7.2 |
8.5 |
15.0520547945205 |
1.34 |
0.73 |
0.5 |
Diabetes Group B |
9 |
9.1 |
1.09848484848485 |
Array2 |
| GSM826990 | M |
Array2_Diabetes3 |
7.1 |
7.9 |
14.75 |
not available |
1.01 |
0.971223021582734 |
Diabetes Group A |
8.1 |
8 |
0.44 |
Array2 |
| GSM826991 | M |
Array2_Diabetes4 |
6.7 |
7.6 |
9.37260273972603 |
not available |
0.34 |
0.39 |
Diabetes Group B |
7.2 |
6.7 |
0.56 |
Array2 |
| GSM826992 | F |
Array2_Diabetes5 |
5.8 |
7.3 |
6.78082191780822 |
0.45 |
0.9 |
1.03 |
Diabetes Group A |
6.4 |
6.4 |
0.44 |
Array2 |
| GSM826993 | F |
Array2_Diabetes6 |
6 |
8.6 |
8.1972602739726 |
not available |
0.42 |
0.42 |
Diabetes Group A |
no visit |
7.6 |
0.45 |
Array2 |
| GSM826994 | F |
Array2_Diabetes7 |
6.4 |
6.8 |
10.8904109589041 |
0.697167755991285 |
no visit |
0.81 |
Diabetes Group A |
6.4 |
6.7 |
0.637254901960784 |
Array2 |
| GSM826995 | F |
Array2_Diabetes8 |
7.7 |
7 |
15.413698630137 |
not available |
0.92 |
0.72 |
Diabetes Group B |
7.1 |
7.9 |
not available |
Array2 |
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