Changes in gene expression profiles in patients with 5q- syndrome in CD14+ monocytes caused by lenalidomide treatment-GSE31460
We detected changes in genes expression in patients with 5q- syndrome in CD14+ monocytes due to treatment with lenalidomide.
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Total RNA was obtained from CD14+ monocytes from peripheral blood of 6 controls, 6 patients before treatment, and 5 patients during treatment.
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Belickova M, Cermak J, Dostalova MM, Vesela J, Krejcik Z, Cechova E,Zemanova Z, Michalova K, Votavova H, Caniga M, Neuwirtova R, Jonasova A
| Sample ID | Gender | !Sample_title | treatment | cell type | disease state |
|---|---|---|---|---|---|
| GSM781858 | M | Healthy donor 1 | n/a | CD14+ monocytes from peripheral blood | Healthy donor |
| GSM781859 | F | Healthy donor 2 | n/a | CD14+ monocytes from peripheral blood | Healthy donor |
| GSM781860 | F | Healthy donor 3 | n/a | CD14+ monocytes from peripheral blood | Healthy donor |
| GSM781861 | M | Healthy donor 4 | n/a | CD14+ monocytes from peripheral blood | Healthy donor |
| GSM781862 | F | Healthy donor 5 | n/a | CD14+ monocytes from peripheral blood | Healthy donor |
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| Sample ID | Gender | !Sample Title | Treatment | Cell type | Disease state | Age in years | Transfusions | I-fish del(5)(q31) | Karyotype |
|---|---|---|---|---|---|---|---|---|---|
| GSM781858 | M |
Healthy donor 1 |
n/a |
CD14+ monocytes from peripheral blood |
Healthy donor |
41 |
no |
N/A |
N/A |
| GSM781859 | F |
Healthy donor 2 |
n/a |
CD14+ monocytes from peripheral blood |
Healthy donor |
39 |
no |
N/A |
N/A |
| GSM781860 | F |
Healthy donor 3 |
n/a |
CD14+ monocytes from peripheral blood |
Healthy donor |
34 |
no |
N/A |
N/A |
| GSM781861 | M |
Healthy donor 4 |
n/a |
CD14+ monocytes from peripheral blood |
Healthy donor |
76 |
no |
N/A |
N/A |
| GSM781862 | F |
Healthy donor 5 |
n/a |
CD14+ monocytes from peripheral blood |
Healthy donor |
54 |
no |
N/A |
N/A |
| GSM781863 | M |
Healthy donor 6 |
n/a |
CD14+ monocytes from peripheral blood |
Healthy donor |
54 |
no |
N/A |
N/A |
| GSM781864 | M |
5q- syndrome before treatment 1 |
baseline |
CD14+ monocytes from peripheral blood |
5q- syndrome before treatment |
63 |
yes |
not done |
46,XY,t(2;11)(p21;q23),del(5)(q13.3q33.3)[20]/46XY[2] |
| GSM781865 | F |
5q- syndrome before treatment 2 |
baseline |
CD14+ monocytes from peripheral blood |
5q- syndrome before treatment |
75 |
yes |
64 |
46,XX,del(5)(q13.3q33.3)[9] /46,XX[11] |
| GSM781866 | F |
5q- syndrome before treatment 3 |
baseline |
CD14+ monocytes from peripheral blood |
5q- syndrome before treatment |
59 |
yes |
49,5 |
46,XX,del(5)(q13.3q33.3)[1] /46,XX[4] |
| GSM781867 | M |
5q- syndrome before treatment 4 |
baseline |
CD14+ monocytes from peripheral blood |
5q- syndrome before treatment |
73 |
yes |
74,5 |
46,XY,del(5)(q13.3q33.3)[7]/46,XY[7] |
| GSM781868 | M |
5q- syndrome before treatment 5 |
baseline |
CD14+ monocytes from peripheral blood |
5q- syndrome before treatment |
55 |
yes |
54 |
46,XY[15] |
| GSM781869 | F |
5q- syndrome before treatment 6 |
baseline |
CD14+ monocytes from peripheral blood |
5q- syndrome before treatment |
72 |
yes |
64,5 |
46,XX,del(5)(q31)[10]/46,XX[5] |
| GSM781870 | M |
5q- syndrome treated lenalidomide (at the time of first erytroid response) 1 |
lenalidomide |
CD14+ monocytes from peripheral blood |
5q- syndrome treated lenalidomide (at the time of first erytroid response) |
63 |
yes |
70 |
46,XY,t(2;11)(p21;q23),del(5)(q13.3q33.3)[4]/46XY[12] |
| GSM781871 | F |
5q- syndrome treated lenalidomide (at the time of first erytroid response) 2 |
lenalidomide |
CD14+ monocytes from peripheral blood |
5q- syndrome treated lenalidomide (at the time of first erytroid response) |
75 |
no |
0 |
46,XX[19] |
| GSM781872 | F |
5q- syndrome treated lenalidomide (at the time of first erytroid response) 3 |
lenalidomide |
CD14+ monocytes from peripheral blood |
5q- syndrome treated lenalidomide (at the time of first erytroid response) |
59 |
no |
not done |
46,XX[22] |
| GSM781873 | M |
5q- syndrome treated lenalidomide (at the time of first erytroid response) 4 |
lenalidomide |
CD14+ monocytes from peripheral blood |
5q- syndrome treated lenalidomide (at the time of first erytroid response) |
55 |
no |
46 |
46,XY,der(2)t(2;5)(p?13;q33),der(5)del(5)(q13.2q33.3)t(2;5)(p?13;q33.3)[7]/46,XY[9] |
| GSM781874 | F |
5q- syndrome treated lenalidomide (at the time of first erytroid response) 5 |
lenalidomide |
CD14+ monocytes from peripheral blood |
5q- syndrome treated lenalidomide (at the time of first erytroid response) |
72 |
no |
not done |
46,XX,del(5)(q31)[4]/46,XX[18] |
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