Temporal transcriptional changes in human monocytes following acute myocardial infarction: The GerMIFs monocyte expression study-GSE28454
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Monocytes play a central role in the inflammatory response that follows acute myocardial infarction (MI). In order to study phenotypic adaptation of this cell type, we investigated patterns of monocyte gene expression in circulating monocytes at various stages of MI. Circulating monocytes were isolated from venous blood of MI patients at three time points: t1: within 6 hours after onset of chest pain (acute phase), t2: 3 days after MI (subacute phase), t3: 90 days after MI (chronic phase). For comparison, we studied a control group (n=21, data to be submitted later) with stable coronary artery disease. Illumina Ref-8 v3.0 microarray arrays were used for whole-genome transcriptional profiling.
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Maouche S, Sager HB, Aherrahrou Z, Belz S, Brocheton J, Proust C, Tennstedt S, Ammerlahn H, Riedel C, Stritzke J, Kurowski V, Rice KM, Goodall AH,Hengstenberg C, Ouwehand WH, Samani NJ, Cambien F, Erdmann J,Schunkert1 H, Diemert Pclick here to enter text
Sample ID | Age | Gender | !Sample_title | cell type | stage of mi infection |
---|---|---|---|---|---|
GSM703192 | 53 | male | Monocyte RNA 6h X4300799014_C_t1 | monocyte | 6h |
GSM703193 | 43 | male | Monocyte RNA 6h X4300799014_E_t1 | monocyte | 6h |
GSM703194 | 71 | male | Monocyte RNA 6h X4300799014_G_t1 | monocyte | 6h |
GSM703195 | 63 | Female | Monocyte RNA 6h X4300799015_E_t1 | monocyte | 6h |
GSM703196 | 80 | male | Monocyte RNA 6h X4300799018_B_t1 | monocyte | 6h |
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Sample ID | Age | Gender | !Sample Title | Cell type | Stage of mi infection |
---|---|---|---|---|---|
GSM703192 | 53 |
male |
Monocyte RNA 6h X4300799014_C_t1 |
monocyte |
6h |
GSM703193 | 43 |
male |
Monocyte RNA 6h X4300799014_E_t1 |
monocyte |
6h |
GSM703194 | 71 |
male |
Monocyte RNA 6h X4300799014_G_t1 |
monocyte |
6h |
GSM703195 | 63 |
Female |
Monocyte RNA 6h X4300799015_E_t1 |
monocyte |
6h |
GSM703196 | 80 |
male |
Monocyte RNA 6h X4300799018_B_t1 |
monocyte |
6h |
GSM703197 | 55 |
male |
Monocyte RNA 6h X4300799018_F_t1 |
monocyte |
6h |
GSM703198 | 66 |
male |
Monocyte RNA 6h X4300799018_H_t1 |
monocyte |
6h |
GSM703199 | 54 |
male |
Monocyte RNA 6h X4300799020_A_t1 |
monocyte |
6h |
GSM703200 | 58 |
male |
Monocyte RNA 6h X4300799020_C_t1 |
monocyte |
6h |
GSM703201 | 30 |
male |
Monocyte RNA 6h X4300799030_B_t1 |
monocyte |
6h |
GSM703202 | 59 |
Female |
Monocyte RNA 6h X4300799030_C_t1 |
monocyte |
6h |
GSM703203 | 72 |
male |
Monocyte RNA 6h X4300799030_D_t1 |
monocyte |
6h |
GSM703204 | 54 |
male |
Monocyte RNA 6h X4300799030_E_t1 |
monocyte |
6h |
GSM703205 | 64 |
male |
Monocyte RNA 6h X4300799030_F_t1 |
monocyte |
6h |
GSM703206 | 72 |
Female |
Monocyte RNA 6h X4300799030_G_t1 |
monocyte |
6h |
GSM703207 | 67 |
male |
Monocyte RNA 6h X4311471114_A_t1 |
monocyte |
6h |
GSM703208 | 69 |
male |
Monocyte RNA 6h X4311471114_B_t1 |
monocyte |
6h |
GSM703209 | 65 |
Female |
Monocyte RNA 6h X4311471114_C_t1 |
monocyte |
6h |
GSM703210 | 48 |
male |
Monocyte RNA 6h X4311471114_E_t1 |
monocyte |
6h |
GSM703211 | 42 |
male |
Monocyte RNA 6h X4311471114_G_t1 |
monocyte |
6h |
GSM703212 | 45 |
male |
Monocyte RNA 6h X4311471115_A_t1 |
monocyte |
6h |
GSM703213 | 54 |
Female |
Monocyte RNA 6h X4311471115_C_t1 |
monocyte |
6h |
GSM703214 | 58 |
Female |
Monocyte RNA 6h X4311471115_E_t1 |
monocyte |
6h |
GSM703215 | 62 |
male |
Monocyte RNA 6h X4311471115_G_t1 |
monocyte |
6h |
GSM703216 | 65 |
Female |
Monocyte RNA 6h X4311471116_C_t1 |
monocyte |
6h |
GSM703217 | 57 |
male |
Monocyte RNA 6h X4311471116_E_t1 |
monocyte |
6h |
GSM703218 | 53 |
male |
Monocyte RNA 72h X4300799014_D_t3 |
monocyte |
72h |
GSM703219 | 43 |
male |
Monocyte RNA 72h X4300799014_F_t3 |
monocyte |
72h |
GSM703220 | 71 |
male |
Monocyte RNA 72h X4300799014_H_t3 |
monocyte |
72h |
GSM703221 | 30 |
male |
Monocyte RNA 72h X4300799015_A_t3 |
monocyte |
72h |
GSM703222 | 59 |
Female |
Monocyte RNA 72h X4300799015_B_t3 |
monocyte |
72h |
GSM703223 | 72 |
male |
Monocyte RNA 72h X4300799015_C_t3 |
monocyte |
72h |
GSM703224 | 54 |
male |
Monocyte RNA 72h X4300799015_D_t3 |
monocyte |
72h |
GSM703225 | 63 |
Female |
Monocyte RNA 72h X4300799015_F_t3 |
monocyte |
72h |
GSM703226 | 64 |
male |
Monocyte RNA 72h X4300799015_G_t3 |
monocyte |
72h |
GSM703227 | 80 |
Female |
Monocyte RNA 72h X4300799015_H_t3 |
monocyte |
72h |
GSM703228 | 67 |
male |
Monocyte RNA 72h X4300799018_A_t3 |
monocyte |
72h |
GSM703229 | 80 |
male |
Monocyte RNA 72h X4300799018_C_t3 |
monocyte |
72h |
GSM703230 | 69 |
male |
Monocyte RNA 72h X4300799018_D_t3 |
monocyte |
72h |
GSM703231 | 65 |
Female |
Monocyte RNA 72h X4300799018_E_t3 |
monocyte |
72h |
GSM703232 | 55 |
male |
Monocyte RNA 72h X4300799018_G_t3 |
monocyte |
72h |
GSM703233 | 54 |
male |
Monocyte RNA 72h X4300799020_B_t3 |
monocyte |
72h |
GSM703234 | 58 |
male |
Monocyte RNA 72h X4300799030_A_t3 |
monocyte |
72h |
GSM703235 | 72 |
Female |
Monocyte RNA 72h X4300799030_H_t3 |
monocyte |
72h |
GSM703236 | 57 |
male |
Monocyte RNA 72h X4300799032_A_t3 |
monocyte |
72h |
GSM703237 | 66 |
male |
Monocyte RNA 72h X4311471114_D_t3 |
monocyte |
72h |
GSM703238 | 48 |
male |
Monocyte RNA 72h X4311471114_F_t3 |
monocyte |
72h |
GSM703239 | 42 |
male |
Monocyte RNA 72h X4311471114_H_t3 |
monocyte |
72h |
GSM703240 | 45 |
male |
Monocyte RNA 72h X4311471115_B_t3 |
monocyte |
72h |
GSM703241 | 54 |
Female |
Monocyte RNA 72h X4311471115_D_t3 |
monocyte |
72h |
GSM703242 | 58 |
Female |
Monocyte RNA 72h X4311471115_F_t3 |
monocyte |
72h |
GSM703243 | 62 |
male |
Monocyte RNA 72h X4311471115_H_t3 |
monocyte |
72h |
GSM703244 | 62 |
male |
Monocyte RNA 72h X4311471116_B_t3 |
monocyte |
72h |
GSM703245 | 65 |
Female |
Monocyte RNA 72h X4311471116_D_t3 |
monocyte |
72h |
GSM703246 | 66 |
male |
Monocyte RNA 90 days X4559291046_A_t90 |
monocyte |
90d |
GSM703247 | 62 |
male |
Monocyte RNA 90 days X4559291046_B_t90 |
monocyte |
90d |
GSM703248 | 43 |
male |
Monocyte RNA 90 days X4559291046_C_t90 |
monocyte |
90d |
GSM703249 | 42 |
male |
Monocyte RNA 90 days X4559291046_D_t90 |
monocyte |
90d |
GSM703250 | 45 |
male |
Monocyte RNA 90 days X4559291046_E_t90 |
monocyte |
90d |
GSM703251 | 62 |
male |
Monocyte RNA 90 days X4559291046_F_t90 |
monocyte |
90d |
GSM703252 | 58 |
male |
Monocyte RNA 90 days X4561606068_A_t90 |
monocyte |
90d |
GSM703253 | 30 |
male |
Monocyte RNA 90 days X4561606068_B_t90 |
monocyte |
90d |
GSM703254 | 72 |
Female |
Monocyte RNA 90 days X4561606068_C_t90 |
monocyte |
90d |
GSM703255 | 55 |
male |
Monocyte RNA 90 days X4561606068_D_t90 |
monocyte |
90d |
GSM703256 | 48 |
male |
Monocyte RNA 90 days X4561606068_E_t90 |
monocyte |
90d |
GSM703257 | 54 |
Female |
Monocyte RNA 90 days X4561606068_F_t90 |
monocyte |
90d |
GSM703258 | 58 |
Female |
Monocyte RNA 90 days X4561606068_G_t90 |
monocyte |
90d |
GSM703259 | 57 |
male |
Monocyte RNA 90 days X4561606068_H_t90 |
monocyte |
90d |
GSM703260 | 80 |
male |
Monocyte RNA 90 days X4561606069_A_t90 |
monocyte |
90d |
GSM703261 | 54 |
male |
Monocyte RNA 90 days X4561606069_B_t90 |
monocyte |
90d |
GSM703262 | 54 |
male |
Monocyte RNA 90 days X4561606069_C_t90 |
monocyte |
90d |
GSM703263 | 53 |
male |
Monocyte RNA 90 days X4561606069_D_t90 |
monocyte |
90d |
GSM703264 | 71 |
male |
Monocyte RNA 90 days X4561606069_E_t90 |
monocyte |
90d |
GSM703265 | 64 |
male |
Monocyte RNA 90 days X4561606069_F_t90 |
monocyte |
90d |
GSM703266 | 67 |
male |
Monocyte RNA 90 days X4561606069_G_t90 |
monocyte |
90d |
GSM703267 | 69 |
male |
Monocyte RNA 90 days X4561606069_H_t90 |
monocyte |
90d |
Name | ||
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