Transcriptome analysis of primary monocytes from HIV+ patients with differential responses to therapy-GSE52900
This study aimed at investigating the monocytic transcriptome distinction between patients with sustained virus suppression (BDL) and patients with virological failure during highly active antiretroviral therapy (HAART).
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Total RNA obtained from primary monocytes from five HIV+ patients on HAART who sustainably controlled HIV below detection level (BDL), five HIV+ patients on HAART who consecutively experienced viremia and four healthy HIV sero-negative controls were compared against each other.
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| Sample ID | !Sample_title | cell type | tissue | disease status | viral load |
|---|---|---|---|---|---|
| GSM1277694 | monocytes_BDL_biorep1 | primary monocytes | peripheral blood | sustained virus suppression | <40 copies/ml |
| GSM1277695 | monocytes_BDL_biorep2 | primary monocytes | peripheral blood | sustained virus suppression | <40 copies/ml |
| GSM1277696 | monocytes_BDL_biorep3 | primary monocytes | peripheral blood | sustained virus suppression | <40 copies/ml |
| GSM1277697 | monocytes_BDL_biorep4 | primary monocytes | peripheral blood | sustained virus suppression | <40 copies/ml |
| GSM1277698 | monocytes_BDL_biorep5 | primary monocytes | peripheral blood | sustained virus suppression | <40 copies/ml |
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| Sample ID | !Sample Title | Cell type | Tissue | Disease status | Viral load |
|---|---|---|---|---|---|
| GSM1277694 | monocytes_BDL_biorep1 |
primary monocytes |
peripheral blood |
sustained virus suppression |
<40 copies/ml |
| GSM1277695 | monocytes_BDL_biorep2 |
primary monocytes |
peripheral blood |
sustained virus suppression |
<40 copies/ml |
| GSM1277696 | monocytes_BDL_biorep3 |
primary monocytes |
peripheral blood |
sustained virus suppression |
<40 copies/ml |
| GSM1277697 | monocytes_BDL_biorep4 |
primary monocytes |
peripheral blood |
sustained virus suppression |
<40 copies/ml |
| GSM1277698 | monocytes_BDL_biorep5 |
primary monocytes |
peripheral blood |
sustained virus suppression |
<40 copies/ml |
| GSM1277699 | monocytes_VIR_biorep1 |
primary monocytes |
peripheral blood |
virological failure |
87 copies/ml |
| GSM1277700 | monocytes_VIR_biorep2 |
primary monocytes |
peripheral blood |
virological failure |
787 copies/ml |
| GSM1277701 | monocytes_VIR_biorep3 |
primary monocytes |
peripheral blood |
virological failure |
194 copies/ml |
| GSM1277702 | monocytes_VIR_biorep4 |
primary monocytes |
peripheral blood |
virological failure |
177 copies/ml |
| GSM1277703 | monocytes_VIR_biorep5 |
primary monocytes |
peripheral blood |
virological failure |
169 copies/ml |
| GSM1277704 | monocytes_ctrl_biorep1 |
primary monocytes |
peripheral blood |
HIV sero-negative healthy controls |
not applicable |
| GSM1277705 | monocytes_ctrl_biorep2 |
primary monocytes |
peripheral blood |
HIV sero-negative healthy controls |
not applicable |
| GSM1277706 | monocytes_ctrl_biorep3 |
primary monocytes |
peripheral blood |
HIV sero-negative healthy controls |
not applicable |
| GSM1277707 | monocytes_ctrl_biorep4 |
primary monocytes |
peripheral blood |
HIV sero-negative healthy controls |
not applicable |
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