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Clinical

Longitudinal comparison of monocytes from an HIV viremic vs avirmeic state-GSE5220

Purpose

Longitudinal analysis of monocyte gene expressions patterns before and after cessation of HAART: understanding the impact of HIV viremia on the monocyte tranascritome.

Hypothesis

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Experimental Design

A longitudinal study was performed on 8 HIV infected individuals looking at gene expression changes in monocytes as a result of rebound of HIV viral load following termination of HAART: 8 patients pre and post HAART cessation.

Experimental Variables

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Controls

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Methods

We used microarrays to detail the global program of gene expression underlying defects in monocytes from HIV infected patients during viremia.

Additional Information
  • Tilton JC, Johnson AJ, Luskin MR, Manion MM et al. Diminished production of monocyte proinflammatory cytokines during human immunodeficiency virus viremia is mediated by type I interferons. J Virol 2006 Dec;80(23):11486-97. PMID: 17005663
  • Microarray
    Affymetrix HG-U133A
    16 Samples Loaded: 16
    Human (Homo sapiens)
    Monocytes
    HIV
    Sample Set Spreadsheet
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    Samples Preview
    Sample ID !Sample_title Status
    GSM118290 aviremic HIV patient A ON HAART
    GSM118291 aviremic HIV patient B ON HAART
    GSM118292 aviremic HIV patient C ON HAART
    GSM118293 aviremic HIV patient D ON HAART
    GSM118294 aviremic HIV patient E ON HAART
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    File
    sampleset4000102_sampleannotations.csv
    Sample Set Spreadsheet
    Raw Signal
    Raw Signal
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    Sample ID !Sample Title Status
    GSM118290
    aviremic HIV patient A
    ON HAART
    GSM118291
    aviremic HIV patient B
    ON HAART
    GSM118292
    aviremic HIV patient C
    ON HAART
    GSM118293
    aviremic HIV patient D
    ON HAART
    GSM118294
    aviremic HIV patient E
    ON HAART
    GSM118295
    aviremic HIV patient F
    ON HAART
    GSM118296
    aviremic HIV patient G
    ON HAART
    GSM118297
    aviremic HIV patient H
    ON HAART
    GSM118298
    viremic HIV patient A
    OFF HAART
    GSM118299
    viremic HIV patient B
    OFF HAART
    GSM118300
    viremic HIV patient C
    OFF HAART
    GSM118301
    viremic HIV patient D
    OFF HAART
    GSM118302
    viremic HIV patient E
    OFF HAART
    GSM118303
    viremic HIV patient F
    OFF HAART
    GSM118304
    viremic HIV patient G
    OFF HAART
    GSM118305
    viremic HIV patient H
    OFF HAART

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