Gene expression profile of human monocytes stimulated with all-trans retinoic acid (ATRA) or 1,25a-dihydroxyvitamin D3 (1,25D3)-GSE46268
A role for vitamin A in host defense against Mycobacterium tuberculosis has been suggested through epidemiological and in vitro studies; however, the antimicrobial mechanism is unclear. Here, we demonstrate that vitamin A mediates host defense through regulation of cellular cholesterol content.
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Monocytes derived from four independent healthy blood donors that were stimulated with control (CTRL), ATRA or 1,25D3 at 10-8M for 18 hours.
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Sample ID | !Sample_title | treatment | cell type | disease state | individual |
---|---|---|---|---|---|
GSM1127890 | monocyte from donor 1 stimulated with CTRL | control | monocyte | healthy | donor 1 |
GSM1127891 | monocyte from donor 2 stimulated with CTRL | control | monocyte | healthy | donor 2 |
GSM1127892 | monocyte from donor 3 stimulated with CTRL | control | monocyte | healthy | donor 3 |
GSM1127893 | monocyte from donor 4 stimulated with CTRL | control | monocyte | healthy | donor 4 |
GSM1127894 | monocyte from donor 1 stimulated with ATRA | all-trans retinoic acid | monocyte | healthy | donor 1 |
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Sample ID | !Sample Title | Treatment | Cell type | Disease state | Individual |
---|---|---|---|---|---|
GSM1127890 | monocyte from donor 1 stimulated with CTRL |
control |
monocyte |
healthy |
donor 1 |
GSM1127891 | monocyte from donor 2 stimulated with CTRL |
control |
monocyte |
healthy |
donor 2 |
GSM1127892 | monocyte from donor 3 stimulated with CTRL |
control |
monocyte |
healthy |
donor 3 |
GSM1127893 | monocyte from donor 4 stimulated with CTRL |
control |
monocyte |
healthy |
donor 4 |
GSM1127894 | monocyte from donor 1 stimulated with ATRA |
all-trans retinoic acid |
monocyte |
healthy |
donor 1 |
GSM1127895 | monocyte from donor 2 stimulated with ATRA |
all-trans retinoic acid |
monocyte |
healthy |
donor 2 |
GSM1127896 | monocyte from donor 3 stimulated with ATRA |
all-trans retinoic acid |
monocyte |
healthy |
donor 3 |
GSM1127897 | monocyte from donor 4 stimulated with ATRA |
all-trans retinoic acid |
monocyte |
healthy |
donor 4 |
GSM1127898 | monocyte from donor 1 stimulated with 1,25D |
1_25a-dihydroxyvitamin D3 |
monocyte |
healthy |
donor 1 |
GSM1127899 | monocyte from donor 2 stimulated with 1,25D |
1_25a-dihydroxyvitamin D3 |
monocyte |
healthy |
donor 2 |
GSM1127900 | monocyte from donor 3 stimulated with 1,25D |
1_25a-dihydroxyvitamin D3 |
monocyte |
healthy |
donor 3 |
GSM1127901 | monocyte from donor 4 stimulated with 1,25D |
1_25a-dihydroxyvitamin D3 |
monocyte |
healthy |
donor 4 |
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