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T helper lymphocyte- and monocyte-specific type I interferon (IFN) signatures in autoimmunity and viral infection-GSE51997

Purpose

his study demonstrates quantitative and qualitative differences between type I IFN signatures in autoimmunity and viral infection using purified CD4pos T cells and CD16pos- ...

Hypothesis

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Experimental Design

Collection of cells from Systemic Lupus Erythematosus (SLE) patients: For CD4pos T cells, six patients with SLE (average age: 29.0 +/- 7.6) and four normal healthy donors ...

Experimental Variables

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Controls

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Methods

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Additional Information
  • Kyogoku C, Smiljanovic B, Grün JR, Biesen R et al. Cell-specific type I IFN signatures in autoimmunity and viral infection: what makes the difference?PLoS One ...
  • Microarray
    Affymetrix HG-U133_Plus_2
    36 Samples Loaded: 36
    Human (Homo sapiens)
    Monocytes , T cells
    Autoimmune Diseases
    Sample Set Spreadsheet
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    Samples Preview
    Sample ID !Sample_title cell type blood donor flow cytometric cell sorting vaccination
    GSM1256958 SLE-patients; Group 1: CD4 T lymphocytes; active SLE 2 CD4 SLE patient CD3posCD4pos none
    GSM1256959 SLE-patients; Group 1: CD4 T lymphocytes; active SLE 4 CD4 SLE patient CD3posCD4pos none
    GSM1256960 SLE-patients; Group 1: CD4 T lymphocytes; active SLE 7 CD4 SLE patient CD3posCD4pos none
    GSM1256961 SLE-patients; Group 1: CD4 T lymphocytes; active SLE 8 CD4 SLE patient CD3posCD4pos none
    GSM1256962 SLE-patients; Group 1: CD4 T lymphocytes; active SLE 9 CD4 SLE patient CD3posCD4pos none
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    sampleset4000076_sampleannotations.csv
    Sample Set Spreadsheet
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    Sample ID !Sample Title Cell type Blood donor Flow cytometric cell sorting Vaccination Sample contiditions
    GSM1256958
    SLE-patients; Group 1: CD4 T lymphocytes; active SLE 2
    CD4
    SLE patient
    CD3posCD4pos
    none
    SLE_CD4
    GSM1256959
    SLE-patients; Group 1: CD4 T lymphocytes; active SLE 4
    CD4
    SLE patient
    CD3posCD4pos
    none
    SLE_CD4
    GSM1256960
    SLE-patients; Group 1: CD4 T lymphocytes; active SLE 7
    CD4
    SLE patient
    CD3posCD4pos
    none
    SLE_CD4
    GSM1256961
    SLE-patients; Group 1: CD4 T lymphocytes; active SLE 8
    CD4
    SLE patient
    CD3posCD4pos
    none
    SLE_CD4
    GSM1256962
    SLE-patients; Group 1: CD4 T lymphocytes; active SLE 9
    CD4
    SLE patient
    CD3posCD4pos
    none
    SLE_CD4
    GSM1256963
    SLE-patients; Group 1: CD4 T lymphocytes; active SLE 12
    CD4
    SLE patient
    CD3posCD4pos
    none
    SLE_CD4
    GSM1256964
    SLE-patients; Group 2: CD16neg, inflammatory monocytes; active SLE 1
    CD16 negative
    SLE patient
    CD15negCD14posCD16neg
    none
    SLE_CD16-
    GSM1256965
    SLE-patients; Group 2: CD16neg, inflammatory monocytes; active SLE 2
    CD16 negative
    SLE patient
    CD15negCD14posCD16neg
    none
    SLE_CD16-
    GSM1256966
    SLE-patients; Group 2: CD16neg, inflammatory monocytes; active SLE 3
    CD16 negative
    SLE patient
    CD15negCD14posCD16neg
    none
    SLE_CD16-
    GSM1256967
    SLE-patients; Group 2: CD16neg, inflammatory monocytes; active SLE 4
    CD16 negative
    SLE patient
    CD15negCD14posCD16neg
    none
    SLE_CD16-
    GSM1256968
    SLE-patients; Group 3: CD16pos, resident monocytes; active SLE 1
    CD16 positive
    SLE patient
    CD15negCD14posCD16pos
    none
    SLE_CD16+
    GSM1256969
    SLE-patients; Group 3: CD16pos, resident monocytes; active SLE 2
    CD16 positive
    SLE patient
    CD15negCD14posCD16pos
    none
    SLE_CD16+
    GSM1256970
    SLE-patients; Group 3: CD16pos, resident monocytes; active SLE 3
    CD16 positive
    SLE patient
    CD15negCD14posCD16pos
    none
    SLE_CD16+
    GSM1256971
    SLE-patients; Group 3: CD16pos, resident monocytes; active SLE 4
    CD16 positive
    SLE patient
    CD15negCD14posCD16pos
    none
    SLE_CD16+
    GSM1256972
    Yellow fever vaccinated NDs; Group 4: CD4 T lymphocytes; ND 54 before YFV
    CD4
    Healthy individual (ND)
    CD3posCD4pos
    none
    CD4
    GSM1256973
    Yellow fever vaccinated NDs; Group 4: CD4 T lymphocytes; ND 55 before YFV
    CD4
    Healthy individual (ND)
    CD3posCD4pos
    none
    CD4
    GSM1256974
    Yellow fever vaccinated NDs; Group 4: CD4 T lymphocytes; ND 56 before YFV
    CD4
    Healthy individual (ND)
    CD3posCD4pos
    none
    CD4
    GSM1256975
    Yellow fever vaccinated NDs; Group 4: CD4 T lymphocytes; ND 57 before YFV
    CD4
    Healthy individual (ND)
    CD3posCD4pos
    none
    CD4
    GSM1256976
    Yellow fever vaccinated NDs; Group 5: CD4 T lymphocytes; ND 54 seven days after YFV
    CD4
    Healthy individual (ND)
    CD3posCD4pos
    7 days after Yellow Fever vaccination
    CD4 after YFV
    GSM1256977
    Yellow fever vaccinated NDs; Group 5: CD4 T lymphocytes; ND 55 seven days after YFV
    CD4
    Healthy individual (ND)
    CD3posCD4pos
    7 days after Yellow Fever vaccination
    CD4 after YFV
    GSM1256978
    Yellow fever vaccinated NDs; Group 5: CD4 T lymphocytes; ND 56 seven days after YFV
    CD4
    Healthy individual (ND)
    CD3posCD4pos
    7 days after Yellow Fever vaccination
    CD4 after YFV
    GSM1256979
    Yellow fever vaccinated NDs; Group 5: CD4 T lymphocytes; ND 57 seven days after YFV
    CD4
    Healthy individual (ND)
    CD3posCD4pos
    7 days after Yellow Fever vaccination
    CD4 after YFV
    GSM1256980
    Yellow fever vaccinated NDs; Group 6: CD16neg, inflammatory monocytes; ND 54 before YFV
    CD16 negative
    Healthy individual (ND)
    CD15negCD14posCD16neg
    none
    CD16-
    GSM1256981
    Yellow fever vaccinated NDs; Group 6: CD16neg, inflammatory monocytes; ND 55 before YFV
    CD16 negative
    Healthy individual (ND)
    CD15negCD14posCD16neg
    none
    CD16-
    GSM1256982
    Yellow fever vaccinated NDs; Group 6: CD16neg, inflammatory monocytes; ND 56 before YFV
    CD16 negative
    Healthy individual (ND)
    CD15negCD14posCD16neg
    none
    CD16-
    GSM1256983
    Yellow fever vaccinated NDs; Group 6: CD16neg, inflammatory monocytes; ND 57 before YFV
    CD16 negative
    Healthy individual (ND)
    CD15negCD14posCD16neg
    none
    CD16-
    GSM1256984
    Yellow fever vaccinated NDs; Group 7: CD16neg, inflammatory monocytes; ND 54 seven days after YFV
    CD16 negative
    Healthy individual (ND)
    CD15negCD14posCD16neg
    7 days after Yellow Fever vaccination
    CD16- after YFV
    GSM1256985
    Yellow fever vaccinated NDs; Group 7: CD16neg, inflammatory monocytes; ND 55 seven days after YFV
    CD16 negative
    Healthy individual (ND)
    CD15negCD14posCD16neg
    7 days after Yellow Fever vaccination
    CD16- after YFV
    GSM1256986
    Yellow fever vaccinated NDs; Group 7: CD16neg, inflammatory monocytes; ND 56 seven days after YFV
    CD16 negative
    Healthy individual (ND)
    CD15negCD14posCD16neg
    7 days after Yellow Fever vaccination
    CD16- after YFV
    GSM1256987
    Yellow fever vaccinated NDs; Group 7: CD16neg, inflammatory monocytes; ND 57 seven days after YFV
    CD16 negative
    Healthy individual (ND)
    CD15negCD14posCD16neg
    7 days after Yellow Fever vaccination
    CD16- after YFV
    GSM1256988
    Yellow fever vaccinated NDs; Group 8: CD16pos, resident monocytes; ND 55 before YFV
    CD16 positive
    Healthy individual (ND)
    CD15negCD14posCD16pos
    none
    CD16+
    GSM1256989
    Yellow fever vaccinated NDs; Group 8: CD16pos, resident monocytes; ND 56 before YFV
    CD16 positive
    Healthy individual (ND)
    CD15negCD14posCD16pos
    none
    CD16+
    GSM1256990
    Yellow fever vaccinated NDs; Group 8: CD16pos, resident monocytes; ND 57 before YFV
    CD16 positive
    Healthy individual (ND)
    CD15negCD14posCD16pos
    none
    CD16+
    GSM1256991
    Yellow fever vaccinated NDs; Group 9: CD16pos, resident monocytes; ND 55 seven days after YFV
    CD16 positive
    Healthy individual (ND)
    CD15negCD14posCD16pos
    7 days after Yellow Fever vaccination
    CD16+ after YFV
    GSM1256992
    Yellow fever vaccinated NDs; Group 9: CD16pos, resident monocytes; ND 56 seven days after YFV
    CD16 positive
    Healthy individual (ND)
    CD15negCD14posCD16pos
    7 days after Yellow Fever vaccination
    CD16+ after YFV
    GSM1256993
    Yellow fever vaccinated NDs; Group 9: CD16pos, resident monocytes; ND 57 seven days after YFV
    CD16 positive
    Healthy individual (ND)
    CD15negCD14posCD16pos
    7 days after Yellow Fever vaccination
    CD16+ after YFV

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