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Clinical

Inflammatory Expression Profiles in Monocyte to Macrophage Differentiation amongst Patients with Systemic Lupus Erythematosus and Healthy Controls with and without an Atherosclerosis Phenotype-GSE37356

Purpose

To examine mononuclear cell gene expression profiles in patients with and without SLE and subsets with and without atherosclerosis

Hypothesis

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Experimental Design

Monocytes were obtained from 20 patients with SLE and 16 healthy controls and were in vitro differentiated into macrophages. Subjects also underwent laboratory and imaging studies of the coronary arteries, carotid arteries, and aorta to evaluate for subclinical atherosclerosis.

Experimental Variables

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Controls

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Methods

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Additional Information

Ramsey-Goldman R, Korman B

Microarray
Illumina HumanHT-12 v4
72 Samples Loaded: 72
Human (Homo sapiens)
Monocytes , Macrophages
Systemic Lupus Erythematosus
Sample Set Spreadsheet
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Samples Preview
Sample ID !Sample_title cell type tissue atherosclerosis status lupus status
GSM916575 L30c mono monocyte blood no control
GSM916576 L30c Mac-MCSF macrophage blood no control
GSM916577 L35c mono (1) monocyte blood yes control
GSM916578 L45 mono monocyte blood no case
GSM916579 L45 Mac-MCSF macrophage blood no case
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File
sampleset4000073_sampleannotations.csv
Sample Set Spreadsheet
Log2 Transformed
Raw Signal
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Clinical Datasource
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Samples Viewer / Editor

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Sample ID !Sample Title Cell type Tissue Atherosclerosis status Lupus status Sample conditions
GSM916575
L30c mono
monocyte
blood
no
control
H_Mono
GSM916576
L30c Mac-MCSF
macrophage
blood
no
control
H_Mac
GSM916577
L35c mono (1)
monocyte
blood
yes
control
H_Mono
GSM916578
L45 mono
monocyte
blood
no
case
SLE_Mono
GSM916579
L45 Mac-MCSF
macrophage
blood
no
case
SLE_Mac
GSM916580
L46c mono
monocyte
blood
yes
control
H_Mono
GSM916581
L46c Mac-MCSF
macrophage
blood
yes
control
H_Mac
GSM916582
L69 Mac-MCSF
macrophage
blood
yes
case
SLE_Mac
GSM916583
L95R Mono
monocyte
blood
no
case
SLE_Mono
GSM916584
L95R Mac-MCSF
macrophage
blood
no
case
SLE_Mac
GSM916585
L124 Mono
monocyte
blood
yes
case
SLE_Mono
GSM916586
L124 Mac-MCSF
macrophage
blood
yes
case
SLE_Mac
GSM916587
L9 mono
monocyte
blood
yes
case
SLE_Mono
GSM916588
L9 Mac-MCSF
macrophage
blood
yes
case
SLE_Mac
GSM916589
L28 mono
monocyte
blood
yes
case
SLE_Mono
GSM916590
L28 Mac-MCSF
macrophage
blood
yes
case
SLE_Mac
GSM916591
L38c mono
monocyte
blood
no
control
H_Mono
GSM916592
L38c Mac-MCSF
macrophage
blood
no
control
H_Mac
GSM916593
L70 mono
monocyte
blood
no
case
SLE_Mono
GSM916594
L70 Mac
macrophage
blood
no
case
SLE_Mac
GSM916595
L56c mono
monocyte
blood
yes
control
H_Mono
GSM916596
L56c Mac-MCSF
macrophage
blood
yes
control
H_Mac
GSM916597
L112 Mono
monocyte
blood
no
case
SLE_Mono
GSM916598
L112 Mac-MCSF
macrophage
blood
no
case
SLE_Mac
GSM916599
L51c mono
monocyte
blood
no
control
H_Mono
GSM916600
L51c Mac-MCSF
macrophage
blood
no
control
H_Mac
GSM916601
L52 mono
monocyte
blood
yes
case
SLE_Mono
GSM916602
L52 Mac-MCSF
macrophage
blood
yes
case
SLE_Mac
GSM916603
L60 mono
monocyte
blood
no
case
SLE_Mono
GSM916604
L60 Mac-MCSF
macrophage
blood
no
case
SLE_Mac
GSM916605
L76c Mono
monocyte
blood
yes
control
H_Mono
GSM916606
L76c Mac-MCSF
macrophage
blood
yes
control
H_Mac
GSM916607
L128 Mono
monocyte
blood
no
case
SLE_Mono
GSM916608
L128 Mac-MCSF
macrophage
blood
no
case
SLE_Mac
GSM916609
L172 Mono
monocyte
blood
yes
case
SLE_Mono
GSM916610
L172 Mac-MCSF
macrophage
blood
yes
case
SLE_Mac
GSM916611
L8 Mac-MCSF
macrophage
blood
no
case
SLE_Mac
GSM916612
L35c Mac-MCSF (1)
macrophage
blood
yes
control
H_Mac
GSM916613
L40 mono
monocyte
blood
yes
case
SLE_Mono
GSM916614
L40 Mac-MCSF
macrophage
blood
yes
case
SLE_Mac
GSM916615
L81c Mono
monocyte
blood
no
control
H_Mono
GSM916616
L81c Mac-MCSF
macrophage
blood
no
control
H_Mac
GSM916617
L106c Mono
monocyte
blood
yes
control
H_Mono
GSM916618
L106c Mac-MCSF
macrophage
blood
yes
control
H_Mac
GSM916619
L130 Mono
monocyte
blood
yes
case
SLE_Mono
GSM916620
L130 Mac-MCSF
macrophage
blood
yes
case
SLE_Mac
GSM916621
L153 Mono
monocyte
blood
no
case
SLE_Mono
GSM916622
L153 Mac-MCSF
macrophage
blood
no
case
SLE_Mac
GSM916623
L35c mono (2)
monocyte
blood
yes
control
H_Mono
GSM916624
L35c Mac-MCSF (2)
macrophage
blood
yes
control
H_Mac
GSM916625
L49 Mac-MCSF
macrophage
blood
no
case
SLE_Mac
GSM916626
L49 mono
monocyte
blood
no
case
SLE_Mono
GSM916627
L64c mono
monocyte
blood
no
control
H_Mono
GSM916628
L64c Mac-MCSF
macrophage
blood
no
control
H_Mac
GSM916629
L114c Mono
monocyte
blood
yes
control
H_Mono
GSM916630
L114c Mac-MCSF
macrophage
blood
yes
control
H_Mac
GSM916631
L164c Mono
monocyte
blood
no
control
H_Mono
GSM916632
L164c Mac-MCSF
macrophage
blood
no
control
H_Mac
GSM916633
L199 Mono
monocyte
blood
yes
case
SLE_Mono
GSM916634
L199 Mac-MCSF
macrophage
blood
yes
case
SLE_Mac
GSM916635
L8 mono
monocyte
blood
no
case
SLE_Mono
GSM916636
L54c mono
monocyte
blood
yes
control
H_Mono
GSM916637
L54c Mac-MCSF
macrophage
blood
yes
control
H_Mac
GSM916638
L69 Mono
monocyte
blood
yes
case
SLE_Mono
GSM916639
L72 Mono
monocyte
blood
no
case
SLE_Mono
GSM916640
L72 Mac-MCSF
macrophage
blood
no
case
SLE_Mac
GSM916641
L75c Mono
monocyte
blood
no
control
H_Mono
GSM916642
L75c Mac-MCSF
macrophage
blood
no
control
H_Mac
GSM916643
L149R Mono
monocyte
blood
yes
case
SLE_Mono
GSM916644
L149R Mac-MCSF
macrophage
blood
yes
case
SLE_Mac
GSM916645
L165c Mono
monocyte
blood
yes
control
H_Mono
GSM916646
L165c Mac-MCSF
macrophage
blood
yes
control
H_Mac

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