Sample Set Annotation Tool: Treatment of human monocytes with TLR7 or TLR8 agonists-GSE64480

Study Design
Assay
Sample Info
Files
Info
Samples
Group Sets
Analysis

Purpose

Goal was to detect differences in response to TLR7 versus TLR8 agonists in human monocytes from healthy donors

Hypothesis

Experimental Design

3 deidentified donors from the Red Cross, monocytes from each donor incubated overnight with either vehicle, TLR7 agonist or TLR8 agonist

Experimental Variables

Controls

Methods

Additional Information

Elavazhagan S, Fatehchand K, Santhanam V, Fang H et al. Granzyme B expression is enhanced in human monocytes by TLR8 agonists and contributes to antibody-dependent cellular cytotoxicity. J Immunol 2015 Mar 15;194(6):2786-95. PMID: 25667415

Expected Samples:

9 Samples Loaded: 9

Species

Human (Homo sapiens)

Sample Source

Monocytes

Disease

Healthy

Treatment Protocol

Growth Protocol

Extraction Protocol

Storage Conditions

Sample Set Spreadsheet

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Samples Preview

Sample ID	!Sample_title	treatment	cell type	individual
GSM1572093	Donor 1 untreated	untreated	monocytes	deidentified donor 1
GSM1572094	Donor 1 TLR7 agonist	TLR7 agonist	monocytes	deidentified donor 1
GSM1572095	Donor 1 TLR8 agonist	TLR8 agonist	monocytes	deidentified donor 1
GSM1572096	Donor 2 untreated	untreated	monocytes	deidentified donor 2
GSM1572097	Donor 2 TLR7 agonist	TLR7 agonist	monocytes	deidentified donor 2

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Sample ID	!Sample Title	Treatment	Cell type	Individual
GSM1572093	Donor 1 untreated	untreated	monocytes	deidentified donor 1
GSM1572094	Donor 1 TLR7 agonist	TLR7 agonist	monocytes	deidentified donor 1
GSM1572095	Donor 1 TLR8 agonist	TLR8 agonist	monocytes	deidentified donor 1
GSM1572096	Donor 2 untreated	untreated	monocytes	deidentified donor 2
GSM1572097	Donor 2 TLR7 agonist	TLR7 agonist	monocytes	deidentified donor 2
GSM1572098	Donor 2 TLR8 agonist	TLR8 agonist	monocytes	deidentified donor 2
GSM1572099	Donor 3 untreated	untreated	monocytes	deidentified donor 3
GSM1572100	Donor 3 TLR7 agonist	TLR7 agonist	monocytes	deidentified donor 3
GSM1572101	Donor 3 TLR8 agonist	TLR8 agonist	monocytes	deidentified donor 3

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SIDRA