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Clinical

Divergent genome wide transcriptional profiles from immune cell subsets isolated from SLE patients with different ancestral backgrounds-GSE55447

Purpose

Systemic lupus erythematosus (SLE) is a complex multi-system autoimmune disease of uncertain etiology. Patients from different ancestral backgrounds demonstrate differences in clinical manifestations and autoantibody profiles. In this study we examined genome-wide transcriptional patterns in major immune cell subsets across different ancestral backgrounds.

Hypothesis

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Experimental Design

eripheral blood was collected from 21 African-American (AA) and 21 European-American (EA) SLE patients, 5 AA controls, and 5 EA controls. CD4+ T-cells, CD8+ T-cells, monocytes and B cells were purified by flow sorting. Each cell subset from each subject was run on an Illumina HumanHT-12 V4 expression BeadChip array (n=208 arrays).

Experimental Variables

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Controls

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Methods

Peripheral blood was collected from 21 African-American (AA) and 21 European-American (EA) SLE patients, 5 AA controls, and 5 EA controls. CD4+ T-cells, CD8+ T-cells, monocytes and B cells were purified by flow sorting. Each cell subset from each subject was run on an Illumina HumanHT-12 V4 expression BeadChip array (n=208 arrays). Differentially expressed genes (DEGs) were determined by comparing cases and controls of the same ancestral background.

Additional Information
  • Sharma S, Jin Z, Rosenzweig E, Rao S et al. Widely divergent transcriptional patterns between SLE patients of different ancestral backgrounds in sorted immune cell populations. J Autoimmun 2015 Jun;60:51-8. PMID: 25921064
  • Microarray
    Illumina HumanHT-12 v4
    208 Samples Loaded: 208
    Human (Homo sapiens)
    B cells , CD8 T cells , CD4 T cells , Monocytes
    Systemic Lupus Erythematosus
    Sample Set Spreadsheet
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    Samples Preview
    Sample ID Gender !Sample_title cell type tissue surface markers used in facs
    GSM1336913 Female AA_Case1_CD4 CD4 positive T cells Peripheral blood CD4-FITC
    GSM1336914 Female AA_Case2_CD4 CD4 positive T cells Peripheral blood CD4-FITC
    GSM1336915 Female AA_Case3_CD4 CD4 positive T cells Peripheral blood CD4-FITC
    GSM1336916 Female AA_Case4_CD4 CD4 positive T cells Peripheral blood CD4-FITC
    GSM1336917 Female AA_Case5_CD4 CD4 positive T cells Peripheral blood CD4-FITC
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    Log2 Transformed
    Raw Signal
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    Sample ID Gender !Sample Title Cell type Tissue Surface markers used in facs Ancestral background Subject condition
    GSM1336913
    Female
    AA_Case1_CD4
    CD4 positive T cells
    Peripheral blood
    CD4-FITC
    African-American (AA)
    Systemic lupus erythematosus (SLE) patient
    GSM1336914
    Female
    AA_Case2_CD4
    CD4 positive T cells
    Peripheral blood
    CD4-FITC
    African-American (AA)
    Systemic lupus erythematosus (SLE) patient
    GSM1336915
    Female
    AA_Case3_CD4
    CD4 positive T cells
    Peripheral blood
    CD4-FITC
    African-American (AA)
    Systemic lupus erythematosus (SLE) patient
    GSM1336916
    Female
    AA_Case4_CD4
    CD4 positive T cells
    Peripheral blood
    CD4-FITC
    African-American (AA)
    Systemic lupus erythematosus (SLE) patient
    GSM1336917
    Female
    AA_Case5_CD4
    CD4 positive T cells
    Peripheral blood
    CD4-FITC
    African-American (AA)
    Systemic lupus erythematosus (SLE) patient
    GSM1336918
    Female
    AA_Case6_CD4
    CD4 positive T cells
    Peripheral blood
    CD4-FITC
    African-American (AA)
    Systemic lupus erythematosus (SLE) patient
    GSM1336919
    Female
    AA_Case7_CD4
    CD4 positive T cells
    Peripheral blood
    CD4-FITC
    African-American (AA)
    Systemic lupus erythematosus (SLE) patient
    GSM1336920
    Female
    AA_Case8_CD4
    CD4 positive T cells
    Peripheral blood
    CD4-FITC
    African-American (AA)
    Systemic lupus erythematosus (SLE) patient
    GSM1336921
    Female
    AA_Case9_CD4
    CD4 positive T cells
    Peripheral blood
    CD4-FITC
    African-American (AA)
    Systemic lupus erythematosus (SLE) patient
    GSM1336922
    Female
    AA_Case10_CD4
    CD4 positive T cells
    Peripheral blood
    CD4-FITC
    African-American (AA)
    Systemic lupus erythematosus (SLE) patient
    GSM1336923
    Female
    AA_Case11_CD4
    CD4 positive T cells
    Peripheral blood
    CD4-FITC
    African-American (AA)
    Systemic lupus erythematosus (SLE) patient
    GSM1336924
    Female
    AA_Case12_CD4
    CD4 positive T cells
    Peripheral blood
    CD4-FITC
    African-American (AA)
    Systemic lupus erythematosus (SLE) patient
    GSM1336925
    Female
    AA_Case13_CD4
    CD4 positive T cells
    Peripheral blood
    CD4-FITC
    African-American (AA)
    Systemic lupus erythematosus (SLE) patient
    GSM1336926
    Female
    AA_Case14_CD4
    CD4 positive T cells
    Peripheral blood
    CD4-FITC
    African-American (AA)
    Systemic lupus erythematosus (SLE) patient
    GSM1336927
    Female
    AA_Case15_CD4
    CD4 positive T cells
    Peripheral blood
    CD4-FITC
    African-American (AA)
    Systemic lupus erythematosus (SLE) patient
    GSM1336928
    Female
    AA_Case16_CD4
    CD4 positive T cells
    Peripheral blood
    CD4-FITC
    African-American (AA)
    Systemic lupus erythematosus (SLE) patient
    GSM1336929
    Female
    AA_Case17_CD4
    CD4 positive T cells
    Peripheral blood
    CD4-FITC
    African-American (AA)
    Systemic lupus erythematosus (SLE) patient
    GSM1336930
    Female
    AA_Case18_CD4
    CD4 positive T cells
    Peripheral blood
    CD4-FITC
    African-American (AA)
    Systemic lupus erythematosus (SLE) patient
    GSM1336931
    Female
    AA_Case19_CD4
    CD4 positive T cells
    Peripheral blood
    CD4-FITC
    African-American (AA)
    Systemic lupus erythematosus (SLE) patient
    GSM1336932
    Female
    AA_Case20_CD4
    CD4 positive T cells
    Peripheral blood
    CD4-FITC
    African-American (AA)
    Systemic lupus erythematosus (SLE) patient
    GSM1336933
    Female
    AA_Case21_CD4
    CD4 positive T cells
    Peripheral blood
    CD4-FITC
    African-American (AA)
    Systemic lupus erythematosus (SLE) patient
    GSM1336934
    Female
    EA_Case1_CD4
    CD4 positive T cells
    Peripheral blood
    CD4-FITC
    European-American (EA)
    Systemic lupus erythematosus (SLE) patient
    GSM1336935
    Female
    EA_Case2_CD4
    CD4 positive T cells
    Peripheral blood
    CD4-FITC
    European-American (EA)
    Systemic lupus erythematosus (SLE) patient
    GSM1336936
    Female
    EA_Case3_CD4
    CD4 positive T cells
    Peripheral blood
    CD4-FITC
    European-American (EA)
    Systemic lupus erythematosus (SLE) patient
    GSM1336937
    Female
    EA_Case4_CD4
    CD4 positive T cells
    Peripheral blood
    CD4-FITC
    European-American (EA)
    Systemic lupus erythematosus (SLE) patient
    GSM1336938
    Female
    EA_Case5_CD4
    CD4 positive T cells
    Peripheral blood
    CD4-FITC
    European-American (EA)
    Systemic lupus erythematosus (SLE) patient
    GSM1336939
    Female
    EA_Case6_CD4
    CD4 positive T cells
    Peripheral blood
    CD4-FITC
    European-American (EA)
    Systemic lupus erythematosus (SLE) patient
    GSM1336940
    Female
    EA_Case7_CD4
    CD4 positive T cells
    Peripheral blood
    CD4-FITC
    European-American (EA)
    Systemic lupus erythematosus (SLE) patient
    GSM1336941
    Female
    EA_Case8_CD4
    CD4 positive T cells
    Peripheral blood
    CD4-FITC
    European-American (EA)
    Systemic lupus erythematosus (SLE) patient
    GSM1336942
    Female
    EA_Case9_CD4
    CD4 positive T cells
    Peripheral blood
    CD4-FITC
    European-American (EA)
    Systemic lupus erythematosus (SLE) patient
    GSM1336943
    Female
    EA_Case10_CD4
    CD4 positive T cells
    Peripheral blood
    CD4-FITC
    European-American (EA)
    Systemic lupus erythematosus (SLE) patient
    GSM1336944
    Female
    EA_Case11_CD4
    CD4 positive T cells
    Peripheral blood
    CD4-FITC
    European-American (EA)
    Systemic lupus erythematosus (SLE) patient
    GSM1336945
    Female
    EA_Case12_CD4
    CD4 positive T cells
    Peripheral blood
    CD4-FITC
    European-American (EA)
    Systemic lupus erythematosus (SLE) patient
    GSM1336946
    Female
    EA_Case13_CD4
    CD4 positive T cells
    Peripheral blood
    CD4-FITC
    European-American (EA)
    Systemic lupus erythematosus (SLE) patient
    GSM1336947
    Female
    EA_Case14_CD4
    CD4 positive T cells
    Peripheral blood
    CD4-FITC
    European-American (EA)
    Systemic lupus erythematosus (SLE) patient
    GSM1336948
    Female
    EA_Case15_CD4
    CD4 positive T cells
    Peripheral blood
    CD4-FITC
    European-American (EA)
    Systemic lupus erythematosus (SLE) patient
    GSM1336949
    Female
    EA_Case16_CD4
    CD4 positive T cells
    Peripheral blood
    CD4-FITC
    European-American (EA)
    Systemic lupus erythematosus (SLE) patient
    GSM1336950
    Female
    EA_Case17_CD4
    CD4 positive T cells
    Peripheral blood
    CD4-FITC
    European-American (EA)
    Systemic lupus erythematosus (SLE) patient
    GSM1336951
    Female
    EA_Case18_CD4
    CD4 positive T cells
    Peripheral blood
    CD4-FITC
    European-American (EA)
    Systemic lupus erythematosus (SLE) patient
    GSM1336952
    Female
    EA_Case19_CD4
    CD4 positive T cells
    Peripheral blood
    CD4-FITC
    European-American (EA)
    Systemic lupus erythematosus (SLE) patient
    GSM1336953
    Female
    EA_Case20_CD4
    CD4 positive T cells
    Peripheral blood
    CD4-FITC
    European-American (EA)
    Systemic lupus erythematosus (SLE) patient
    GSM1336954
    Female
    EA_Case21_CD4
    CD4 positive T cells
    Peripheral blood
    CD4-FITC
    European-American (EA)
    Systemic lupus erythematosus (SLE) patient
    GSM1336955
    Female
    AA_Control1_CD4
    CD4 positive T cells
    Peripheral blood
    CD4-FITC
    African-American (AA)
    Systemic lupus erythematosus (SLE) patient
    GSM1336956
    Female
    AA_Control2_CD4
    CD4 positive T cells
    Peripheral blood
    CD4-FITC
    African-American (AA)
    Systemic lupus erythematosus (SLE) patient
    GSM1336957
    Female
    AA_Control3_CD4
    CD4 positive T cells
    Peripheral blood
    CD4-FITC
    African-American (AA)
    Systemic lupus erythematosus (SLE) patient
    GSM1336958
    Female
    AA_Control4_CD4
    CD4 positive T cells
    Peripheral blood
    CD4-FITC
    African-American (AA)
    Systemic lupus erythematosus (SLE) patient
    GSM1336959
    Female
    AA_Control5_CD4
    CD4 positive T cells
    Peripheral blood
    CD4-FITC
    African-American (AA)
    Systemic lupus erythematosus (SLE) patient
    GSM1336960
    Female
    EA_Control1_CD4
    CD4 positive T cells
    Peripheral blood
    CD4-FITC
    European-American (EA)
    Systemic lupus erythematosus (SLE) patient
    GSM1336961
    Female
    EA_Control2_CD4
    CD4 positive T cells
    Peripheral blood
    CD4-FITC
    European-American (EA)
    Systemic lupus erythematosus (SLE) patient
    GSM1336962
    Female
    EA_Control3_CD4
    CD4 positive T cells
    Peripheral blood
    CD4-FITC
    European-American (EA)
    Systemic lupus erythematosus (SLE) patient
    GSM1336963
    Female
    EA_Control4_CD4
    CD4 positive T cells
    Peripheral blood
    CD4-FITC
    European-American (EA)
    Systemic lupus erythematosus (SLE) patient
    GSM1336964
    Female
    EA_Control5_CD4
    CD4 positive T cells
    Peripheral blood
    CD4-FITC
    European-American (EA)
    Systemic lupus erythematosus (SLE) patient
    GSM1336965
    Female
    AA_Case1_CD8
    CD8 positive T cells
    Peripheral blood
    CD8-PE
    African-American (AA)
    Systemic lupus erythematosus (SLE) patient
    GSM1336966
    Female
    AA_Case2_CD8
    CD8 positive T cells
    Peripheral blood
    CD8-PE
    African-American (AA)
    Systemic lupus erythematosus (SLE) patient
    GSM1336967
    Female
    AA_Case3_CD8
    CD8 positive T cells
    Peripheral blood
    CD8-PE
    African-American (AA)
    Systemic lupus erythematosus (SLE) patient
    GSM1336968
    Female
    AA_Case4_CD8
    CD8 positive T cells
    Peripheral blood
    CD8-PE
    African-American (AA)
    Systemic lupus erythematosus (SLE) patient
    GSM1336969
    Female
    AA_Case5_CD8
    CD8 positive T cells
    Peripheral blood
    CD8-PE
    African-American (AA)
    Systemic lupus erythematosus (SLE) patient
    GSM1336970
    Female
    AA_Case6_CD8
    CD8 positive T cells
    Peripheral blood
    CD8-PE
    African-American (AA)
    Systemic lupus erythematosus (SLE) patient
    GSM1336971
    Female
    AA_Case7_CD8
    CD8 positive T cells
    Peripheral blood
    CD8-PE
    African-American (AA)
    Systemic lupus erythematosus (SLE) patient
    GSM1336972
    Female
    AA_Case8_CD8
    CD8 positive T cells
    Peripheral blood
    CD8-PE
    African-American (AA)
    Systemic lupus erythematosus (SLE) patient
    GSM1336973
    Female
    AA_Case9_CD8
    CD8 positive T cells
    Peripheral blood
    CD8-PE
    African-American (AA)
    Systemic lupus erythematosus (SLE) patient
    GSM1336974
    Female
    AA_Case10_CD8
    CD8 positive T cells
    Peripheral blood
    CD8-PE
    African-American (AA)
    Systemic lupus erythematosus (SLE) patient
    GSM1336975
    Female
    AA_Case11_CD8
    CD8 positive T cells
    Peripheral blood
    CD8-PE
    African-American (AA)
    Systemic lupus erythematosus (SLE) patient
    GSM1336976
    Female
    AA_Case12_CD8
    CD8 positive T cells
    Peripheral blood
    CD8-PE
    African-American (AA)
    Systemic lupus erythematosus (SLE) patient
    GSM1336977
    Female
    AA_Case13_CD8
    CD8 positive T cells
    Peripheral blood
    CD8-PE
    African-American (AA)
    Systemic lupus erythematosus (SLE) patient
    GSM1336978
    Female
    AA_Case14_CD8
    CD8 positive T cells
    Peripheral blood
    CD8-PE
    African-American (AA)
    Systemic lupus erythematosus (SLE) patient
    GSM1336979
    Female
    AA_Case15_CD8
    CD8 positive T cells
    Peripheral blood
    CD8-PE
    African-American (AA)
    Systemic lupus erythematosus (SLE) patient
    GSM1336980
    Female
    AA_Case16_CD8
    CD8 positive T cells
    Peripheral blood
    CD8-PE
    African-American (AA)
    Systemic lupus erythematosus (SLE) patient
    GSM1336981
    Female
    AA_Case17_CD8
    CD8 positive T cells
    Peripheral blood
    CD8-PE
    African-American (AA)
    Systemic lupus erythematosus (SLE) patient
    GSM1336982
    Female
    AA_Case18_CD8
    CD8 positive T cells
    Peripheral blood
    CD8-PE
    African-American (AA)
    Systemic lupus erythematosus (SLE) patient
    GSM1336983
    Female
    AA_Case19_CD8
    CD8 positive T cells
    Peripheral blood
    CD8-PE
    African-American (AA)
    Systemic lupus erythematosus (SLE) patient
    GSM1336984
    Female
    AA_Case20_CD8
    CD8 positive T cells
    Peripheral blood
    CD8-PE
    African-American (AA)
    Systemic lupus erythematosus (SLE) patient
    GSM1336985
    Female
    AA_Case21_CD8
    CD8 positive T cells
    Peripheral blood
    CD8-PE
    African-American (AA)
    Systemic lupus erythematosus (SLE) patient
    GSM1336986
    Female
    EA_Case1_CD8
    CD8 positive T cells
    Peripheral blood
    CD8-PE
    European-American (EA)
    Systemic lupus erythematosus (SLE) patient
    GSM1336987
    Female
    EA_Case2_CD8
    CD8 positive T cells
    Peripheral blood
    CD8-PE
    European-American (EA)
    Systemic lupus erythematosus (SLE) patient
    GSM1336988
    Female
    EA_Case3_CD8
    CD8 positive T cells
    Peripheral blood
    CD8-PE
    European-American (EA)
    Systemic lupus erythematosus (SLE) patient
    GSM1336989
    Female
    EA_Case4_CD8
    CD8 positive T cells
    Peripheral blood
    CD8-PE
    European-American (EA)
    Systemic lupus erythematosus (SLE) patient
    GSM1336990
    Female
    EA_Case5_CD8
    CD8 positive T cells
    Peripheral blood
    CD8-PE
    European-American (EA)
    Systemic lupus erythematosus (SLE) patient
    GSM1336991
    Female
    EA_Case6_CD8
    CD8 positive T cells
    Peripheral blood
    CD8-PE
    European-American (EA)
    Systemic lupus erythematosus (SLE) patient
    GSM1336992
    Female
    EA_Case7_CD8
    CD8 positive T cells
    Peripheral blood
    CD8-PE
    European-American (EA)
    Systemic lupus erythematosus (SLE) patient
    GSM1336993
    Female
    EA_Case8_CD8
    CD8 positive T cells
    Peripheral blood
    CD8-PE
    European-American (EA)
    Systemic lupus erythematosus (SLE) patient
    GSM1336994
    Female
    EA_Case9_CD8
    CD8 positive T cells
    Peripheral blood
    CD8-PE
    European-American (EA)
    Systemic lupus erythematosus (SLE) patient
    GSM1336995
    Female
    EA_Case10_CD8
    CD8 positive T cells
    Peripheral blood
    CD8-PE
    European-American (EA)
    Systemic lupus erythematosus (SLE) patient
    GSM1336996
    Female
    EA_Case11_CD8
    CD8 positive T cells
    Peripheral blood
    CD8-PE
    European-American (EA)
    Systemic lupus erythematosus (SLE) patient
    GSM1336997
    Female
    EA_Case12_CD8
    CD8 positive T cells
    Peripheral blood
    CD8-PE
    European-American (EA)
    Systemic lupus erythematosus (SLE) patient
    GSM1336998
    Female
    EA_Case13_CD8
    CD8 positive T cells
    Peripheral blood
    CD8-PE
    European-American (EA)
    Systemic lupus erythematosus (SLE) patient
    GSM1336999
    Female
    EA_Case14_CD8
    CD8 positive T cells
    Peripheral blood
    CD8-PE
    European-American (EA)
    Systemic lupus erythematosus (SLE) patient
    GSM1337000
    Female
    EA_Case15_CD8
    CD8 positive T cells
    Peripheral blood
    CD8-PE
    European-American (EA)
    Systemic lupus erythematosus (SLE) patient
    GSM1337001
    Female
    EA_Case16_CD8
    CD8 positive T cells
    Peripheral blood
    CD8-PE
    European-American (EA)
    Systemic lupus erythematosus (SLE) patient
    GSM1337002
    Female
    EA_Case17_CD8
    CD8 positive T cells
    Peripheral blood
    CD8-PE
    European-American (EA)
    Systemic lupus erythematosus (SLE) patient
    GSM1337003
    Female
    EA_Case18_CD8
    CD8 positive T cells
    Peripheral blood
    CD8-PE
    European-American (EA)
    Systemic lupus erythematosus (SLE) patient
    GSM1337004
    Female
    EA_Case19_CD8
    CD8 positive T cells
    Peripheral blood
    CD8-PE
    European-American (EA)
    Systemic lupus erythematosus (SLE) patient
    GSM1337005
    Female
    EA_Case20_CD8
    CD8 positive T cells
    Peripheral blood
    CD8-PE
    European-American (EA)
    Systemic lupus erythematosus (SLE) patient
    GSM1337006
    Female
    EA_Case21_CD8
    CD8 positive T cells
    Peripheral blood
    CD8-PE
    European-American (EA)
    Systemic lupus erythematosus (SLE) patient
    GSM1337007
    Female
    AA_Control1_CD8
    CD8 positive T cells
    Peripheral blood
    CD8-PE
    African-American (AA)
    healthy control
    GSM1337008
    Female
    AA_Control2_CD8
    CD8 positive T cells
    Peripheral blood
    CD8-PE
    African-American (AA)
    healthy control
    GSM1337009
    Female
    AA_Control3_CD8
    CD8 positive T cells
    Peripheral blood
    CD8-PE
    African-American (AA)
    healthy control
    GSM1337010
    Female
    AA_Control4_CD8
    CD8 positive T cells
    Peripheral blood
    CD8-PE
    African-American (AA)
    healthy control
    GSM1337011
    Female
    AA_Control5_CD8
    CD8 positive T cells
    Peripheral blood
    CD8-PE
    African-American (AA)
    healthy control
    GSM1337012
    Female
    EA_Control1_CD8
    CD8 positive T cells
    Peripheral blood
    CD8-PE
    European-American (EA)
    healthy control
    GSM1337013
    Female
    EA_Control2_CD8
    CD8 positive T cells
    Peripheral blood
    CD8-PE
    European-American (EA)
    healthy control
    GSM1337014
    Female
    EA_Control3_CD8
    CD8 positive T cells
    Peripheral blood
    CD8-PE
    European-American (EA)
    healthy control
    GSM1337015
    Female
    EA_Control4_CD8
    CD8 positive T cells
    Peripheral blood
    CD8-PE
    European-American (EA)
    healthy control
    GSM1337016
    Female
    EA_Control5_CD8
    CD8 positive T cells
    Peripheral blood
    CD8-PE
    European-American (EA)
    healthy control
    GSM1337017
    Female
    AA_Case1_CD14
    CD14 positive monocytes
    Peripheral blood
    CD14-PerCP
    African-American (AA)
    Systemic lupus erythematosus (SLE) patient
    GSM1337018
    Female
    AA_Case2_CD14
    CD14 positive monocytes
    Peripheral blood
    CD14-PerCP
    African-American (AA)
    Systemic lupus erythematosus (SLE) patient
    GSM1337019
    Female
    AA_Case3_CD14
    CD14 positive monocytes
    Peripheral blood
    CD14-PerCP
    African-American (AA)
    Systemic lupus erythematosus (SLE) patient
    GSM1337020
    Female
    AA_Case4_CD14
    CD14 positive monocytes
    Peripheral blood
    CD14-PerCP
    African-American (AA)
    Systemic lupus erythematosus (SLE) patient
    GSM1337021
    Female
    AA_Case5_CD14
    CD14 positive monocytes
    Peripheral blood
    CD14-PerCP
    African-American (AA)
    Systemic lupus erythematosus (SLE) patient
    GSM1337022
    Female
    AA_Case6_CD14
    CD14 positive monocytes
    Peripheral blood
    CD14-PerCP
    African-American (AA)
    Systemic lupus erythematosus (SLE) patient
    GSM1337023
    Female
    AA_Case7_CD14
    CD14 positive monocytes
    Peripheral blood
    CD14-PerCP
    African-American (AA)
    Systemic lupus erythematosus (SLE) patient
    GSM1337024
    Female
    AA_Case8_CD14
    CD14 positive monocytes
    Peripheral blood
    CD14-PerCP
    African-American (AA)
    Systemic lupus erythematosus (SLE) patient
    GSM1337025
    Female
    AA_Case9_CD14
    CD14 positive monocytes
    Peripheral blood
    CD14-PerCP
    African-American (AA)
    Systemic lupus erythematosus (SLE) patient
    GSM1337026
    Female
    AA_Case10_CD14
    CD14 positive monocytes
    Peripheral blood
    CD14-PerCP
    African-American (AA)
    Systemic lupus erythematosus (SLE) patient
    GSM1337027
    Female
    AA_Case11_CD14
    CD14 positive monocytes
    Peripheral blood
    CD14-PerCP
    African-American (AA)
    Systemic lupus erythematosus (SLE) patient
    GSM1337028
    Female
    AA_Case12_CD14
    CD14 positive monocytes
    Peripheral blood
    CD14-PerCP
    African-American (AA)
    Systemic lupus erythematosus (SLE) patient
    GSM1337029
    Female
    AA_Case13_CD14
    CD14 positive monocytes
    Peripheral blood
    CD14-PerCP
    African-American (AA)
    Systemic lupus erythematosus (SLE) patient
    GSM1337030
    Female
    AA_Case14_CD14
    CD14 positive monocytes
    Peripheral blood
    CD14-PerCP
    African-American (AA)
    Systemic lupus erythematosus (SLE) patient
    GSM1337031
    Female
    AA_Case15_CD14
    CD14 positive monocytes
    Peripheral blood
    CD14-PerCP
    African-American (AA)
    Systemic lupus erythematosus (SLE) patient
    GSM1337032
    Female
    AA_Case16_CD14
    CD14 positive monocytes
    Peripheral blood
    CD14-PerCP
    African-American (AA)
    Systemic lupus erythematosus (SLE) patient
    GSM1337033
    Female
    AA_Case17_CD14
    CD14 positive monocytes
    Peripheral blood
    CD14-PerCP
    African-American (AA)
    Systemic lupus erythematosus (SLE) patient
    GSM1337034
    Female
    AA_Case18_CD14
    CD14 positive monocytes
    Peripheral blood
    CD14-PerCP
    African-American (AA)
    Systemic lupus erythematosus (SLE) patient
    GSM1337035
    Female
    AA_Case19_CD14
    CD14 positive monocytes
    Peripheral blood
    CD14-PerCP
    African-American (AA)
    Systemic lupus erythematosus (SLE) patient
    GSM1337036
    Female
    AA_Case20_CD14
    CD14 positive monocytes
    Peripheral blood
    CD14-PerCP
    African-American (AA)
    Systemic lupus erythematosus (SLE) patient
    GSM1337037
    Female
    AA_Case21_CD14
    CD14 positive monocytes
    Peripheral blood
    CD14-PerCP
    African-American (AA)
    Systemic lupus erythematosus (SLE) patient
    GSM1337038
    Female
    EA_Case1_CD14
    CD14 positive monocytes
    Peripheral blood
    CD14-PerCP
    European-American (EA)
    Systemic lupus erythematosus (SLE) patient
    GSM1337039
    Female
    EA_Case2_CD14
    CD14 positive monocytes
    Peripheral blood
    CD14-PerCP
    European-American (EA)
    Systemic lupus erythematosus (SLE) patient
    GSM1337040
    Female
    EA_Case3_CD14
    CD14 positive monocytes
    Peripheral blood
    CD14-PerCP
    European-American (EA)
    Systemic lupus erythematosus (SLE) patient
    GSM1337041
    Female
    EA_Case4_CD14
    CD14 positive monocytes
    Peripheral blood
    CD14-PerCP
    European-American (EA)
    Systemic lupus erythematosus (SLE) patient
    GSM1337042
    Female
    EA_Case5_CD14
    CD14 positive monocytes
    Peripheral blood
    CD14-PerCP
    European-American (EA)
    Systemic lupus erythematosus (SLE) patient
    GSM1337043
    Female
    EA_Case6_CD14
    CD14 positive monocytes
    Peripheral blood
    CD14-PerCP
    European-American (EA)
    Systemic lupus erythematosus (SLE) patient
    GSM1337044
    Female
    EA_Case7_CD14
    CD14 positive monocytes
    Peripheral blood
    CD14-PerCP
    European-American (EA)
    Systemic lupus erythematosus (SLE) patient
    GSM1337045
    Female
    EA_Case8_CD14
    CD14 positive monocytes
    Peripheral blood
    CD14-PerCP
    European-American (EA)
    Systemic lupus erythematosus (SLE) patient
    GSM1337046
    Female
    EA_Case9_CD14
    CD14 positive monocytes
    Peripheral blood
    CD14-PerCP
    European-American (EA)
    Systemic lupus erythematosus (SLE) patient
    GSM1337047
    Female
    EA_Case10_CD14
    CD14 positive monocytes
    Peripheral blood
    CD14-PerCP
    European-American (EA)
    Systemic lupus erythematosus (SLE) patient
    GSM1337048
    Female
    EA_Case11_CD14
    CD14 positive monocytes
    Peripheral blood
    CD14-PerCP
    European-American (EA)
    Systemic lupus erythematosus (SLE) patient
    GSM1337049
    Female
    EA_Case12_CD14
    CD14 positive monocytes
    Peripheral blood
    CD14-PerCP
    European-American (EA)
    Systemic lupus erythematosus (SLE) patient
    GSM1337050
    Female
    EA_Case13_CD14
    CD14 positive monocytes
    Peripheral blood
    CD14-PerCP
    European-American (EA)
    Systemic lupus erythematosus (SLE) patient
    GSM1337051
    Female
    EA_Case14_CD14
    CD14 positive monocytes
    Peripheral blood
    CD14-PerCP
    European-American (EA)
    Systemic lupus erythematosus (SLE) patient
    GSM1337052
    Female
    EA_Case15_CD14
    CD14 positive monocytes
    Peripheral blood
    CD14-PerCP
    European-American (EA)
    Systemic lupus erythematosus (SLE) patient
    GSM1337053
    Female
    EA_Case16_CD14
    CD14 positive monocytes
    Peripheral blood
    CD14-PerCP
    European-American (EA)
    Systemic lupus erythematosus (SLE) patient
    GSM1337054
    Female
    EA_Case17_CD14
    CD14 positive monocytes
    Peripheral blood
    CD14-PerCP
    European-American (EA)
    Systemic lupus erythematosus (SLE) patient
    GSM1337055
    Female
    EA_Case18_CD14
    CD14 positive monocytes
    Peripheral blood
    CD14-PerCP
    European-American (EA)
    Systemic lupus erythematosus (SLE) patient
    GSM1337056
    Female
    EA_Case19_CD14
    CD14 positive monocytes
    Peripheral blood
    CD14-PerCP
    European-American (EA)
    Systemic lupus erythematosus (SLE) patient
    GSM1337057
    Female
    EA_Case20_CD14
    CD14 positive monocytes
    Peripheral blood
    CD14-PerCP
    European-American (EA)
    Systemic lupus erythematosus (SLE) patient
    GSM1337058
    Female
    EA_Case21_CD14
    CD14 positive monocytes
    Peripheral blood
    CD14-PerCP
    European-American (EA)
    Systemic lupus erythematosus (SLE) patient
    GSM1337059
    Female
    AA_Control1_CD14
    CD14 positive monocytes
    Peripheral blood
    CD14-PerCP
    African-American (AA)
    healthy control
    GSM1337060
    Female
    AA_Control2_CD14
    CD14 positive monocytes
    Peripheral blood
    CD14-PerCP
    African-American (AA)
    healthy control
    GSM1337061
    Female
    AA_Control3_CD14
    CD14 positive monocytes
    Peripheral blood
    CD14-PerCP
    African-American (AA)
    healthy control
    GSM1337062
    Female
    AA_Control4_CD14
    CD14 positive monocytes
    Peripheral blood
    CD14-PerCP
    African-American (AA)
    healthy control
    GSM1337063
    Female
    AA_Control5_CD14
    CD14 positive monocytes
    Peripheral blood
    CD14-PerCP
    African-American (AA)
    healthy control
    GSM1337064
    Female
    EA_Control1_CD14
    CD14 positive monocytes
    Peripheral blood
    CD14-PerCP
    European-American (EA)
    healthy control
    GSM1337065
    Female
    EA_Control2_CD14
    CD14 positive monocytes
    Peripheral blood
    CD14-PerCP
    European-American (EA)
    healthy control
    GSM1337066
    Female
    EA_Control3_CD14
    CD14 positive monocytes
    Peripheral blood
    CD14-PerCP
    European-American (EA)
    healthy control
    GSM1337067
    Female
    EA_Control4_CD14
    CD14 positive monocytes
    Peripheral blood
    CD14-PerCP
    European-American (EA)
    healthy control
    GSM1337068
    Female
    EA_Control5_CD14
    CD14 positive monocytes
    Peripheral blood
    CD14-PerCP
    European-American (EA)
    healthy control
    GSM1337069
    Female
    AA_Case1_CD20
    CD20 positive B cells
    Peripheral blood
    CD20-APC
    African-American (AA)
    Systemic lupus erythematosus (SLE) patient
    GSM1337070
    Female
    AA_Case2_CD20
    CD20 positive B cells
    Peripheral blood
    CD20-APC
    African-American (AA)
    Systemic lupus erythematosus (SLE) patient
    GSM1337071
    Female
    AA_Case3_CD20
    CD20 positive B cells
    Peripheral blood
    CD20-APC
    African-American (AA)
    Systemic lupus erythematosus (SLE) patient
    GSM1337072
    Female
    AA_Case4_CD20
    CD20 positive B cells
    Peripheral blood
    CD20-APC
    African-American (AA)
    Systemic lupus erythematosus (SLE) patient
    GSM1337073
    Female
    AA_Case5_CD20
    CD20 positive B cells
    Peripheral blood
    CD20-APC
    African-American (AA)
    Systemic lupus erythematosus (SLE) patient
    GSM1337074
    Female
    AA_Case6_CD20
    CD20 positive B cells
    Peripheral blood
    CD20-APC
    African-American (AA)
    Systemic lupus erythematosus (SLE) patient
    GSM1337075
    Female
    AA_Case7_CD20
    CD20 positive B cells
    Peripheral blood
    CD20-APC
    African-American (AA)
    Systemic lupus erythematosus (SLE) patient
    GSM1337076
    Female
    AA_Case8_CD20
    CD20 positive B cells
    Peripheral blood
    CD20-APC
    African-American (AA)
    Systemic lupus erythematosus (SLE) patient
    GSM1337077
    Female
    AA_Case9_CD20
    CD20 positive B cells
    Peripheral blood
    CD20-APC
    African-American (AA)
    Systemic lupus erythematosus (SLE) patient
    GSM1337078
    Female
    AA_Case10_CD20
    CD20 positive B cells
    Peripheral blood
    CD20-APC
    African-American (AA)
    Systemic lupus erythematosus (SLE) patient
    GSM1337079
    Female
    AA_Case11_CD20
    CD20 positive B cells
    Peripheral blood
    CD20-APC
    African-American (AA)
    Systemic lupus erythematosus (SLE) patient
    GSM1337080
    Female
    AA_Case12_CD20
    CD20 positive B cells
    Peripheral blood
    CD20-APC
    African-American (AA)
    Systemic lupus erythematosus (SLE) patient
    GSM1337081
    Female
    AA_Case13_CD20
    CD20 positive B cells
    Peripheral blood
    CD20-APC
    African-American (AA)
    Systemic lupus erythematosus (SLE) patient
    GSM1337082
    Female
    AA_Case14_CD20
    CD20 positive B cells
    Peripheral blood
    CD20-APC
    African-American (AA)
    Systemic lupus erythematosus (SLE) patient
    GSM1337083
    Female
    AA_Case15_CD20
    CD20 positive B cells
    Peripheral blood
    CD20-APC
    African-American (AA)
    Systemic lupus erythematosus (SLE) patient
    GSM1337084
    Female
    AA_Case16_CD20
    CD20 positive B cells
    Peripheral blood
    CD20-APC
    African-American (AA)
    Systemic lupus erythematosus (SLE) patient
    GSM1337085
    Female
    AA_Case17_CD20
    CD20 positive B cells
    Peripheral blood
    CD20-APC
    African-American (AA)
    Systemic lupus erythematosus (SLE) patient
    GSM1337086
    Female
    AA_Case18_CD20
    CD20 positive B cells
    Peripheral blood
    CD20-APC
    African-American (AA)
    Systemic lupus erythematosus (SLE) patient
    GSM1337087
    Female
    AA_Case19_CD20
    CD20 positive B cells
    Peripheral blood
    CD20-APC
    African-American (AA)
    Systemic lupus erythematosus (SLE) patient
    GSM1337088
    Female
    AA_Case20_CD20
    CD20 positive B cells
    Peripheral blood
    CD20-APC
    African-American (AA)
    Systemic lupus erythematosus (SLE) patient
    GSM1337089
    Female
    AA_Case21_CD20
    CD20 positive B cells
    Peripheral blood
    CD20-APC
    African-American (AA)
    Systemic lupus erythematosus (SLE) patient
    GSM1337090
    Female
    EA_Case1_CD20
    CD20 positive B cells
    Peripheral blood
    CD20-APC
    European-American (EA)
    Systemic lupus erythematosus (SLE) patient
    GSM1337091
    Female
    EA_Case2_CD20
    CD20 positive B cells
    Peripheral blood
    CD20-APC
    European-American (EA)
    Systemic lupus erythematosus (SLE) patient
    GSM1337092
    Female
    EA_Case3_CD20
    CD20 positive B cells
    Peripheral blood
    CD20-APC
    European-American (EA)
    Systemic lupus erythematosus (SLE) patient
    GSM1337093
    Female
    EA_Case4_CD20
    CD20 positive B cells
    Peripheral blood
    CD20-APC
    European-American (EA)
    Systemic lupus erythematosus (SLE) patient
    GSM1337094
    Female
    EA_Case5_CD20
    CD20 positive B cells
    Peripheral blood
    CD20-APC
    European-American (EA)
    Systemic lupus erythematosus (SLE) patient
    GSM1337095
    Female
    EA_Case6_CD20
    CD20 positive B cells
    Peripheral blood
    CD20-APC
    European-American (EA)
    Systemic lupus erythematosus (SLE) patient
    GSM1337096
    Female
    EA_Case7_CD20
    CD20 positive B cells
    Peripheral blood
    CD20-APC
    European-American (EA)
    Systemic lupus erythematosus (SLE) patient
    GSM1337097
    Female
    EA_Case8_CD20
    CD20 positive B cells
    Peripheral blood
    CD20-APC
    European-American (EA)
    Systemic lupus erythematosus (SLE) patient
    GSM1337098
    Female
    EA_Case9_CD20
    CD20 positive B cells
    Peripheral blood
    CD20-APC
    European-American (EA)
    Systemic lupus erythematosus (SLE) patient
    GSM1337099
    Female
    EA_Case10_CD20
    CD20 positive B cells
    Peripheral blood
    CD20-APC
    European-American (EA)
    Systemic lupus erythematosus (SLE) patient
    GSM1337100
    Female
    EA_Case11_CD20
    CD20 positive B cells
    Peripheral blood
    CD20-APC
    European-American (EA)
    Systemic lupus erythematosus (SLE) patient
    GSM1337101
    Female
    EA_Case12_CD20
    CD20 positive B cells
    Peripheral blood
    CD20-APC
    European-American (EA)
    Systemic lupus erythematosus (SLE) patient
    GSM1337102
    Female
    EA_Case13_CD20
    CD20 positive B cells
    Peripheral blood
    CD20-APC
    European-American (EA)
    Systemic lupus erythematosus (SLE) patient
    GSM1337103
    Female
    EA_Case14_CD20
    CD20 positive B cells
    Peripheral blood
    CD20-APC
    European-American (EA)
    Systemic lupus erythematosus (SLE) patient
    GSM1337104
    Female
    EA_Case15_CD20
    CD20 positive B cells
    Peripheral blood
    CD20-APC
    European-American (EA)
    Systemic lupus erythematosus (SLE) patient
    GSM1337105
    Female
    EA_Case16_CD20
    CD20 positive B cells
    Peripheral blood
    CD20-APC
    European-American (EA)
    Systemic lupus erythematosus (SLE) patient
    GSM1337106
    Female
    EA_Case17_CD20
    CD20 positive B cells
    Peripheral blood
    CD20-APC
    European-American (EA)
    Systemic lupus erythematosus (SLE) patient
    GSM1337107
    Female
    EA_Case18_CD20
    CD20 positive B cells
    Peripheral blood
    CD20-APC
    European-American (EA)
    Systemic lupus erythematosus (SLE) patient
    GSM1337108
    Female
    EA_Case19_CD20
    CD20 positive B cells
    Peripheral blood
    CD20-APC
    European-American (EA)
    Systemic lupus erythematosus (SLE) patient
    GSM1337109
    Female
    EA_Case20_CD20
    CD20 positive B cells
    Peripheral blood
    CD20-APC
    European-American (EA)
    Systemic lupus erythematosus (SLE) patient
    GSM1337110
    Female
    EA_Case21_CD20
    CD20 positive B cells
    Peripheral blood
    CD20-APC
    European-American (EA)
    Systemic lupus erythematosus (SLE) patient
    GSM1337111
    Female
    AA_Control1_CD20
    CD20 positive B cells
    Peripheral blood
    CD20-APC
    African-American (AA)
    healthy control
    GSM1337112
    Female
    AA_Control2_CD20
    CD20 positive B cells
    Peripheral blood
    CD20-APC
    African-American (AA)
    healthy control
    GSM1337113
    Female
    AA_Control3_CD20
    CD20 positive B cells
    Peripheral blood
    CD20-APC
    African-American (AA)
    healthy control
    GSM1337114
    Female
    AA_Control4_CD20
    CD20 positive B cells
    Peripheral blood
    CD20-APC
    African-American (AA)
    healthy control
    GSM1337115
    Female
    AA_Control5_CD20
    CD20 positive B cells
    Peripheral blood
    CD20-APC
    African-American (AA)
    healthy control
    GSM1337116
    Female
    EA_Control1_CD20
    CD20 positive B cells
    Peripheral blood
    CD20-APC
    European-American (EA)
    healthy control
    GSM1337117
    Female
    EA_Control2_CD20
    CD20 positive B cells
    Peripheral blood
    CD20-APC
    European-American (EA)
    healthy control
    GSM1337118
    Female
    EA_Control3_CD20
    CD20 positive B cells
    Peripheral blood
    CD20-APC
    European-American (EA)
    healthy control
    GSM1337119
    Female
    EA_Control4_CD20
    CD20 positive B cells
    Peripheral blood
    CD20-APC
    European-American (EA)
    healthy control
    GSM1337120
    Female
    EA_Control5_CD20
    CD20 positive B cells
    Peripheral blood
    CD20-APC
    European-American (EA)
    healthy control

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