You are not logged in. | Log in
In Progress
Clinical

Analysis of blood myelomonocytic cells from RCC patients-GSE38424

Purpose

Myelomonocytic cells (i.e., monocytes or macrophages) play a key role in tumor progression as revealed by numerous mice tumor model studies. However, their contribution in human tumor progression is not well-studied. Using Renal Cell Carcinoma (RCC) as a model for human cancer, we performed a transcriptomal profiling of blood monocytes from RCC patients to investigate the contribution of these cells in cancer progression.

Hypothesis

--

Experimental Design

Blood monocytes from RCC patients (with early or metastatic disease) or healthy donors (controls) were isolated, and then differential gene expression was detected with Limma.

Experimental Variables

--

Controls

--

Methods

--

Additional Information
  • Chittezhath M, Dhillon MK, Lim JY, Laoui D et al. Molecular profiling reveals a tumor-promoting phenotype of monocytes and macrophages in human cancer progression. Immunity 2014 Nov 20;41(5):815-29. PMID: 25453823
  • Microarray
    Illumina HumanHT-12 v4
    8 Samples Loaded: 8
    Human (Homo sapiens)
    Monocytes
    Renal Cell Carcinoma
    Sample Set Spreadsheet
    Please log in in order to upload files.
    Samples Preview
    Sample ID !Sample_title cell type disease state
    GSM941952 Mononcyte-healthy-untreated-1 monocytes healthy
    GSM941953 Mononcyte-healthy-untreated-2 monocytes healthy
    GSM941954 Mononcyte-healthy-untreated-3 monocytes healthy
    GSM941955 Mononcyte-healthy-untreated-4 monocytes healthy
    GSM941956 Monocyte-RCC-untreated-1 monocytes renal cell carcinoma (RCC)
    Please log in in order to upload files.
    File
    Log2 Transformed
    Raw Signal
    •   |  View in GXB »
    Clinical Datasource
    Links

    Samples Viewer / Editor

    All fields are editable except the "Sample ID" column. To edit a cell, click within the cell. To edit a "date" cell, click on the calendar icon. To cancel an edit, press the ESC key.

    Sample ID !Sample Title Cell type Disease state
    GSM941952
    Mononcyte-healthy-untreated-1
    monocytes
    healthy
    GSM941953
    Mononcyte-healthy-untreated-2
    monocytes
    healthy
    GSM941954
    Mononcyte-healthy-untreated-3
    monocytes
    healthy
    GSM941955
    Mononcyte-healthy-untreated-4
    monocytes
    healthy
    GSM941956
    Monocyte-RCC-untreated-1
    monocytes
    renal cell carcinoma (RCC)
    GSM941957
    Monocyte-RCC-untreated-2
    monocytes
    renal cell carcinoma (RCC)
    GSM941959
    Monocyte-RCC-untreated-4
    monocytes
    renal cell carcinoma (RCC)
    GSM941960
    Monocyte-RCC-untreated-5
    monocytes
    renal cell carcinoma (RCC)

    Group Sets View in Gene Expression Browser

    Name  
    All Samples   View
    Disease status Default  View
    In order to make new Group Sets or change settings, please log in.

    Module Analysis

    Group Set  
    All Samples
    Disease status
    Your bug report has been sent!