Ubiquinol-induced gene expression signatures are translated into reduced erythropoiesis and LDL cholesterol levels in humans-GSE21351
- To determine this function in relationship to physiological readouts, a 2-week supplementation study with the reduced form of CoQ10 (ubiquinol, Q10H2, 150 mg/d) was performed in 53 healthy males.
- Transcriptomic and bioinformatic approaches identified a gene-gene interaction network in CD14-positive monocytes, which functions in inflammation, cell differentiation and PPAR-signaling.
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Whole genome expression profiles were analyzed in isolated monocytes of 3 Q10H2 supplemented subjects at the indicated time points (before (T0) and after (T14) Q10H2 supplementation. This results in a total of 6 microarrays.
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| Sample ID | Gender | !Sample_title | time | disease state |
|---|---|---|---|---|
| GSM533554 | male | monocytes_T0_rep1 | 0 | healthy |
| GSM533555 | male | monocytes_T0_rep2 | 0 | healthy |
| GSM533556 | male | monocytes_T0_rep3 | 0 | healthy |
| GSM533557 | male | monocytes_T14_rep1 | 14 | healthy |
| GSM533558 | male | monocytes_T14_rep2 | 14 | healthy |
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| Sample ID | Gender | !Sample Title | Time | Disease state |
|---|---|---|---|---|
| GSM533554 | male |
monocytes_T0_rep1 |
0 |
healthy |
| GSM533555 | male |
monocytes_T0_rep2 |
0 |
healthy |
| GSM533556 | male |
monocytes_T0_rep3 |
0 |
healthy |
| GSM533557 | male |
monocytes_T14_rep1 |
14 |
healthy |
| GSM533558 | male |
monocytes_T14_rep2 |
14 |
healthy |
| GSM533559 | male |
monocytes_T14_rep3 |
14 |
healthy |
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