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Clinical

Ubiquinol-induced gene expression signatures are translated into reduced erythropoiesis and LDL cholesterol levels in humans-GSE21351

Purpose

- To determine this function in relationship to physiological readouts, a 2-week supplementation study with the reduced form of CoQ10 (ubiquinol, Q10H2, 150 mg/d) was performed in 53 healthy males.

- Transcriptomic and bioinformatic approaches identified a gene-gene interaction network in CD14-positive monocytes, which functions in inflammation, cell differentiation and PPAR-signaling.

Hypothesis

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Experimental Design

Whole genome expression profiles were analyzed in isolated monocytes of 3 Q10H2 supplemented subjects at the indicated time points (before (T0) and after (T14) Q10H2 supplementation. This results in a total of 6 microarrays.

Experimental Variables

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Controls

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Methods

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Additional Information
  • Schmelzer C, Niklowitz P, Okun JG, Haas D et al. Ubiquinol-induced gene expression signatures are translated into altered parameters of erythropoiesis and reduced low density lipoprotein cholesterol levels in humans. IUBMB Life2011 Jan;63(1):42-8. PMID: 21280176
  • Microarray
    Affymetrix HG-U133_Plus_2
    6 Samples Loaded: 6
    Human (Homo sapiens)
    Monocytes , B cells
    Healthy
    Sample Set Spreadsheet
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    Samples Preview
    Sample ID Gender !Sample_title time disease state
    GSM533554 male monocytes_T0_rep1 0 healthy
    GSM533555 male monocytes_T0_rep2 0 healthy
    GSM533556 male monocytes_T0_rep3 0 healthy
    GSM533557 male monocytes_T14_rep1 14 healthy
    GSM533558 male monocytes_T14_rep2 14 healthy
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    File
    sampleset4000039_sampleannotations.csv
    Sample Set Spreadsheet
    Raw Signal
    Raw Signal
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    Sample ID Gender !Sample Title Time Disease state
    GSM533554
    male
    monocytes_T0_rep1
    0
    healthy
    GSM533555
    male
    monocytes_T0_rep2
    0
    healthy
    GSM533556
    male
    monocytes_T0_rep3
    0
    healthy
    GSM533557
    male
    monocytes_T14_rep1
    14
    healthy
    GSM533558
    male
    monocytes_T14_rep2
    14
    healthy
    GSM533559
    male
    monocytes_T14_rep3
    14
    healthy

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