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Clinical

TREM-1 is a novel therapeutic target in Psoriasis-GSE42305

Purpose

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Hypothesis

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Experimental Design

Monocytes were isolated by plastic adherence, treated with TLR agonists overnight, washed twice and harvested in RTL-buffer. RNA was extracted and processed for microarray.3 groups and 3 replicates with a paired structure across replicates

Experimental Variables

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Controls

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Methods

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Additional Information
  • Hyder LA, Gonzalez J, Harden JL, Johnson-Huang LM et al. TREM-1 as a potential therapeutic target in psoriasis. J Invest Dermatol 2013 Jul;133(7):1742-51. PMID: 23407402
  • Microarray
    Affymetrix HG-U133A
    15 Samples Loaded: 15
    Human (Homo sapiens)
    Monocytes
    Psoriasis
    Sample Set Spreadsheet
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    Samples Preview
    Sample ID !Sample_title cell type replicates treated with Treatment conditions
    GSM1038141 Control-aster monocytes aster Control
    GSM1038142 Control-U monocytes U Control
    GSM1038143 Control-Y monocytes Y Control
    GSM1038144 HKLM-aster monocytes aster HKLM (10^8 cells/ml InvivoGen) HKLM
    GSM1038145 HKLM-U monocytes U HKLM (10^8 cells/ml InvivoGen) HKLM
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    File
    sampleset4000026_sampleannotations.csv
    Sample Set Spreadsheet
    Log2 Transformed
    Raw Signal
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    Clinical Datasource
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    Sample ID !Sample Title Cell type Replicates Treated with Treatment conditions
    GSM1038141
    Control-aster
    monocytes
    aster
     
    Control
    GSM1038142
    Control-U
    monocytes
    U
     
    Control
    GSM1038143
    Control-Y
    monocytes
    Y
     
    Control
    GSM1038144
    HKLM-aster
    monocytes
    aster
    HKLM (10^8 cells/ml InvivoGen)
    HKLM
    GSM1038145
    HKLM-U
    monocytes
    U
    HKLM (10^8 cells/ml InvivoGen)
    HKLM
    GSM1038146
    HKLM-Y
    monocytes
    Y
    HKLM (10^8 cells/ml InvivoGen)
    HKLM
    GSM1038147
    PNG-aster
    monocytes
    aster
    PGN (5 micrograms/ml, InvivoGen)
    PGN
    GSM1038148
    PNG-U
    monocytes
    U
    PGN (5 micrograms/ml, InvivoGen)
    PGN
    GSM1038149
    PNG-Y
    monocytes
    Y
    PGN (5 micrograms/ml, InvivoGen)
    PGN
    GSM1038150
    BD2-aster
    monocytes
    aster
    BD2 (5 micrograms/ml, Peprotech)
    BD2
    GSM1038151
    BD2-U
    monocytes
    U
    BD2 (5 micrograms/ml, Peprotech)
    BD2
    GSM1038152
    BD2-Y
    monocytes
    Y
    BD2 (5 micrograms/ml, Peprotech)
    BD2
    GSM1038153
    BD3-aster
    monocytes
    aster
    BD3 (20 micrograms/ml, Peprotech)
    BD3
    GSM1038154
    BD3-U
    monocytes
    U
    BD3 (20 micrograms/ml, Peprotech)
    BD3
    GSM1038155
    BD3-Y
    monocytes
    Y
    BD3 (20 micrograms/ml, Peprotech)
    BD3

    Group Sets View in Gene Expression Browser

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