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Clinical

Traffic-related Particulate Matter Upregulates Allergic Responses by a Notch-pathway Dependent Mechanism-GSE34025

Purpose

The mechanisms by which diesel exhaust particles act as an adjuvant are unknown. We hypothesized that these would be mediated through monocyte interactions with DEP.We sought to identify pathways with a role in inflammation or other signaling mechanisms that might demonstrate the mechanism of response to DEP.

Hypothesis

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Experimental Design

Cultured human monocytes from healthy donors were cultured in the presence or absence of diesel exhaust particles. RNA was extracted following culture to determine changes in gene expression pathways.

Experimental Variables

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Controls

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Methods

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Additional Information

Viera-Hutchins L, McGhee SA, Garcia-Lloret M, Chatila ZK, Girion SA, Caja R,Wise P, Ning Z, Sioutas C, Chatila TA

Microarray
Affymetrix HG-U133_Plus_2
16 Samples Loaded: 16
Human (Homo sapiens)
Monocytes
Healthy
Sample Set Spreadsheet
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Samples Preview
Sample ID !Sample_title cell type Treatment conditions
GSM840578 SA.0 cultured monocytes Control
GSM840579 SA.DEP cultured monocytes DEP
GSM840580 SB.0 cultured monocytes Control
GSM840581 SB.DEP cultured monocytes DEP
GSM840582 S17.0 cultured monocytes Control
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File
sampleset4000022_sampleannotations.csv
Sample Set Spreadsheet
Log2 Transformed
Raw Signal
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Sample ID !Sample Title Cell type Treatment conditions
GSM840578
SA.0
cultured monocytes
Control
GSM840579
SA.DEP
cultured monocytes
DEP
GSM840580
SB.0
cultured monocytes
Control
GSM840581
SB.DEP
cultured monocytes
DEP
GSM840582
S17.0
cultured monocytes
Control
GSM840583
S17.DEP
cultured monocytes
DEP
GSM840584
S18.0
cultured monocytes
Control
GSM840585
S18.DEP
cultured monocytes
DEP
GSM840586
S19.0
cultured monocytes
Control
GSM840587
S19.DEP
cultured monocytes
DEP
GSM840588
S20.0
cultured monocytes
Control
GSM840589
S20.DEP
cultured monocytes
DEP
GSM840590
S22.0
cultured monocytes
Control
GSM840591
S22.DEP
cultured monocytes
DEP
GSM840592
S21.0
cultured monocytes
Control
GSM840593
S21.DEP
cultured monocytes
DEP

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