Subpopulations of CD163 positive macrophages are classically activated in psoriasis-GSE18686
To determine the transcriptional profile associated with macrophage polarization to M1 or M2, we cultured macrophages derived from monocytes for 7 days and treated them with IFNg, IL-4, TNF, LPS, and LPS+IFNg (n=7). Psoriasis lesional and non-lesional skin biopsies were included (n=5 pairs).
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Comparison of the transcriptome of psoriasis with cytokine-treated macrophages.
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Sample ID | !Sample_title | cell type | tissue | treatment group | disease status |
---|---|---|---|---|---|
GSM464201 | Macrophage culture, ID 1, Control | cultured macrophages | control | ||
GSM464202 | Macrophage culture, ID 1, IL17 | cultured macrophages | IL17 | ||
GSM464203 | Macrophage culture, ID 1, IFNg | cultured macrophages | IFNg | ||
GSM464204 | Macrophage culture, ID 1, IL4 | cultured macrophages | IL4 | ||
GSM464205 | Macrophage culture, ID 1, TNFa | cultured macrophages | TNFa |
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Sample ID | !Sample Title | Cell type | Tissue | Treatment group | Disease status | Batch | ID | Line |
---|---|---|---|---|---|---|---|---|
GSM464201 | Macrophage culture, ID 1, Control |
cultured macrophages |
control |
14 |
1 |
A |
||
GSM464202 | Macrophage culture, ID 1, IL17 |
cultured macrophages |
IL17 |
14 |
1 |
B |
||
GSM464203 | Macrophage culture, ID 1, IFNg |
cultured macrophages |
IFNg |
14 |
1 |
C |
||
GSM464204 | Macrophage culture, ID 1, IL4 |
cultured macrophages |
IL4 |
14 |
1 |
D |
||
GSM464205 | Macrophage culture, ID 1, TNFa |
cultured macrophages |
TNFa |
14 |
1 |
E |
||
GSM464206 | Macrophage culture, ID 1, LPS |
cultured macrophages |
LPS |
14 |
1 |
F |
||
GSM464207 | Macrophage culture, ID 1, LPSandIFNg |
cultured macrophages |
LPS and IFNg |
14 |
1 |
G |
||
GSM464208 | Macrophage culture, ID 2, Control |
cultured macrophages |
control |
14 |
2 |
H |
||
GSM464209 | Macrophage culture, ID 2, IL17 |
cultured macrophages |
IL17 |
14 |
2 |
I |
||
GSM464210 | Macrophage culture, ID 2, IFNg |
cultured macrophages |
IFNg |
14 |
2 |
J |
||
GSM464211 | Macrophage culture, ID 2, IL4 |
cultured macrophages |
IL4 |
14 |
2 |
K |
||
GSM464212 | Macrophage culture, ID 2, TNFa |
cultured macrophages |
TNFa |
14 |
2 |
L |
||
GSM464213 | Macrophage culture, ID 2, LPS |
cultured macrophages |
LPS |
16 |
2 |
A |
||
GSM464214 | Macrophage culture, ID 2, LPSandIFNg |
cultured macrophages |
LPS and IFNg |
16 |
2 |
B |
||
GSM464215 | Macrophage culture, ID 3, Control |
cultured macrophages |
control |
16 |
3 |
C |
||
GSM464216 | Macrophage culture, ID 3, IL17 |
cultured macrophages |
IL17 |
16 |
3 |
D |
||
GSM464217 | Macrophage culture, ID 3, IFNg |
cultured macrophages |
IFNg |
16 |
3 |
E |
||
GSM464218 | Macrophage culture, ID 3, IL4 |
cultured macrophages |
IL4 |
16 |
3 |
F |
||
GSM464219 | Macrophage culture, ID 3, TNFa |
cultured macrophages |
TNFa |
16 |
3 |
G |
||
GSM464220 | Macrophage culture, ID 3, LPS |
cultured macrophages |
LPS |
16 |
3 |
H |
||
GSM464221 | Macrophage culture, ID 3, LPSandIFNg |
cultured macrophages |
LPS and IFNg |
16 |
3 |
I |
||
GSM464222 | Macrophage culture, ID 4, Control |
cultured macrophages |
control |
16 |
4 |
J |
||
GSM464223 | Macrophage culture, ID 4, IL17 |
cultured macrophages |
IL17 |
16 |
4 |
K |
||
GSM464224 | Macrophage culture, ID 4, IFNg |
cultured macrophages |
IFNg |
16 |
4 |
L |
||
GSM464225 | Macrophage culture, ID 4, IL4 |
cultured macrophages |
IL4 |
69 |
4 |
A |
||
GSM464226 | Macrophage culture, ID 4, TNFa |
cultured macrophages |
TNFa |
69 |
4 |
B |
||
GSM464227 | Macrophage culture, ID 4, LPS |
cultured macrophages |
LPS |
69 |
4 |
C |
||
GSM464228 | Macrophage culture, ID 4, LPSandIFNg |
cultured macrophages |
LPS and IFNg |
69 |
4 |
D |
||
GSM464229 | Macrophage culture, ID 4, Control (rep) |
cultured macrophages |
control |
69 |
4 |
E |
||
GSM464230 | Macrophage culture, ID 4, IL17 (rep) |
cultured macrophages |
IL17 |
69 |
4 |
F |
||
GSM464231 | Macrophage culture, ID 4, IFNg (rep) |
cultured macrophages |
IFNg |
69 |
4 |
G |
||
GSM464232 | Macrophage culture, ID 4, IL4 (rep) |
cultured macrophages |
IL4 |
69 |
4 |
H |
||
GSM464233 | Macrophage culture, ID 4, TNFa (rep) |
cultured macrophages |
TNFa |
69 |
4 |
I |
||
GSM464234 | Macrophage culture, ID 4, LPS (rep) |
cultured macrophages |
LPS |
69 |
4 |
J |
||
GSM464235 | Macrophage culture, ID 4, LPSandIFNg (rep) |
cultured macrophages |
LPS and IFNg |
69 |
4 |
K |
||
GSM464236 | Macrophage culture, ID 5, Control |
cultured macrophages |
control |
71 |
5 |
A |
||
GSM464237 | Macrophage culture, ID 5, IL17 |
cultured macrophages |
IL17 |
71 |
5 |
B |
||
GSM464238 | Macrophage culture, ID 5, IFNg |
cultured macrophages |
IFNg |
71 |
5 |
C |
||
GSM464239 | Macrophage culture, ID 5, IL4 |
cultured macrophages |
IL4 |
71 |
5 |
D |
||
GSM464240 | Macrophage culture, ID 5, TNFa |
cultured macrophages |
TNFa |
71 |
5 |
E |
||
GSM464241 | Macrophage culture, ID 5, LPS |
cultured macrophages |
LPS |
71 |
5 |
F |
||
GSM464242 | Macrophage culture, ID 5, LPSandIFNg |
cultured macrophages |
LPS and IFNg |
71 |
5 |
G |
||
GSM464243 | Macrophage culture, ID 6, IL17 |
cultured macrophages |
IL17 |
71 |
6 |
I |
||
GSM464244 | Macrophage culture, ID 6, IFNg |
cultured macrophages |
IFNg |
71 |
6 |
J |
||
GSM464245 | Macrophage culture, ID 6, IL4 |
cultured macrophages |
IL4 |
71 |
6 |
K |
||
GSM464246 | Macrophage culture, ID 6, TNFa |
cultured macrophages |
TNFa |
71 |
6 |
L |
||
GSM464247 | Macrophage culture, ID 6, LPS |
cultured macrophages |
LPS |
71 |
6 |
A |
||
GSM464248 | Macrophage culture, ID 6, LPSandIFNg |
cultured macrophages |
LPS and IFNg |
35 |
6 |
B |
||
GSM464249 | Psoriasis skin, ID P 001, NL |
skin |
Non-Lesional |
non-lesional psoriasis |
35 |
P 001 |
C |
|
GSM464250 | Psoriasis skin, ID P 002, LS |
skin |
Lesional |
lesional psoriasis |
35 |
P 001 |
D |
|
GSM464251 | Psoriasis skin, ID P 003, NL |
skin |
Non-Lesional |
non-lesional psoriasis |
35 |
P 002 |
E |
|
GSM464252 | Psoriasis skin, ID P 004, LS |
skin |
Lesional |
lesional psoriasis |
35 |
P 002 |
F |
|
GSM464253 | Psoriasis skin, ID P 005, NL |
skin |
Non-Lesional |
non-lesional psoriasis |
35 |
P 003 |
G |
|
GSM464254 | Psoriasis skin, ID P 006, LS |
skin |
Lesional |
lesional psoriasis |
35 |
P 003 |
H |
|
GSM464255 | Psoriasis skin, ID P 007, NL |
skin |
Non-Lesional |
non-lesional psoriasis |
35 |
P 004 |
I |
|
GSM464256 | Psoriasis skin, ID P 008, LS |
skin |
Lesional |
lesional psoriasis |
35 |
P 004 |
J |
|
GSM464257 | Psoriasis skin, ID P 009, NL |
skin |
Non-Lesional |
non-lesional psoriasis |
35 |
P 005 |
K |
|
GSM464258 | Psoriasis skin, ID P 010, LS |
skin |
Lesional |
lesional psoriasis |
35 |
P 005 |
L |
Name | ||
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