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Innate immune repsonses to TREM-1 activation-GSE9988

In Progress
Clinical

Innate immune repsonses to TREM-1 activation-GSE9988

Purpose

To investigate the cellular consequences of TREM-1 activation, we have characterized global gene expression changes in human monocytes in response to TREM-1 cross-linking in comparison to and combined with LPS.

Hypothesis

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Experimental Design

11 anonymous donors were treated with Vehicle, isotype control antibody, TREM1 antibody, LPS, isotype control antibody plus LPS and TREM1 antibody plus LPS

Experimental Variables

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Controls

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Methods

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Additional Information
  • Dower K, Ellis DK, Saraf K, Jelinsky SA et al. Innate immune responses to TREM-1 activation: overlap, divergence, and positive and negative cross-talk with bacterial lipopolysaccharide. J Immunol 2008 Mar 1;180(5):3520-34. PMID: 18292579
    • Microarray
    Affymetrix HG-U133_Plus_2
    62 Samples Loaded: 62
    Human (Homo sapiens)
    Monocytes
    Healthy
    Sample Set Spreadsheet
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    Samples Preview
    Sample ID !Sample_title treatment Anonymous Donor Donor number
    GSM252423 Anti-Trem1 2 hrs Donor 1 aTREM1 True Donor 1
    GSM252424 Anti-Trem1 2 hrs Donor 3 aTREM1 True Donor 3
    GSM252425 Anti-Trem1 2 hrs Donor 11 aTREM1 True Donor 11
    GSM252426 Anti-Trem1 2 hrs Donor 9 aTREM1 True Donor 9
    GSM252427 Anti-Trem1 2 hrs Donor 5 aTREM1 True Donor 5

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    Browse Files

    File
    sampleset4000011_sampleannotations.csv
    Sample Set Spreadsheet
    Raw Signal
    Raw Signal
    •   |  View in GXB »
    Clinical Datasource
    Links
    http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE9988
    http://www.ncbi.nlm.nih.gov/pubmed/18292579

    Samples Viewer / Editor

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    Sample ID !Sample Title Treatment Anonymous Donor Donor number
    GSM252423
    Anti-Trem1 2 hrs Donor 1
    aTREM1
    True
    Donor 1
    GSM252424
    Anti-Trem1 2 hrs Donor 3
    aTREM1
    True
    Donor 3
    GSM252425
    Anti-Trem1 2 hrs Donor 11
    aTREM1
    True
    Donor 11
    GSM252426
    Anti-Trem1 2 hrs Donor 9
    aTREM1
    True
    Donor 9
    GSM252427
    Anti-Trem1 2 hrs Donor 5
    aTREM1
    True
    Donor 5
    GSM252428
    Anti-Trem1 2 hrs Donor 10
    aTREM1
    True
    Donor 10
    GSM252429
    Anti-Trem1 2 hrs Donor 2
    aTREM1
    True
    Donor 2
    GSM252430
    Anti-Trem1 2 hrs Donor 7
    aTREM1
    True
    Donor 7
    GSM252431
    Anti-Trem1 2 hrs Donor 6
    aTREM1
    True
    Donor 6
    GSM252432
    Anti-Trem1 2 hrs Donor 4
    aTREM1
    True
    Donor 4
    GSM252433
    Anti-Trem1 2 hrs Donor 8
    aTREM1
    True
    Donor 8
    GSM252434
    Control/LPS 2 hrs Donor 9
    LPS Control
    True
    Donor 9
    GSM252435
    Control/LPS 2 hrs Donor 5
    LPS Control
    True
    Donor 5
    GSM252436
    Control/LPS 2 hrs Donor 4
    LPS Control
    True
    Donor 4
    GSM252437
    Control/LPS 2 hrs Donor 10
    LPS Control
    True
    Donor 10
    GSM252438
    Control/LPS 2 hrs Donor 8
    LPS Control
    True
    Donor 8
    GSM252439
    Control/LPS 2 hrs Donor 7
    LPS Control
    True
    Donor 7
    GSM252440
    Control/LPS 2 hrs Donor 2
    LPS Control
    True
    Donor 2
    GSM252441
    Control/LPS 2 hrs Donor 3
    LPS Control
    True
    Donor 3
    GSM252442
    Control/LPS 2 hrs Donor 6
    LPS Control
    True
    Donor 6
    GSM252443
    LPS Low 2 hrs Donor 7
    Low LPS
    True
    Donor 7
    GSM252444
    LPS Low 2 hrs Donor 4
    Low LPS
    True
    Donor 4
    GSM252445
    LPS Low 2 hrs Donor 10
    Low LPS
    True
    Donor 10
    GSM252447
    LPS Low 2 hrs Donor 3
    Low LPS
    True
    Donor 3
    GSM252448
    LPS Low 2 hrs Donor 2
    Low LPS
    True
    Donor 2
    GSM252449
    LPS Low 2 hrs Donor 9
    Low LPS
    True
    Donor 9
    GSM252450
    LPS Low 2 hrs Donor 5
    Low LPS
    True
    Donor 5
    GSM252451
    LPS Low 2 hrs Donor 1
    Low LPS
    True
    Donor 1
    GSM252452
    LPS Low 2 hrs Donor 6
    Low LPS
    True
    Donor 6
    GSM252453
    LPS Low 2 hrs Donor 11
    Low LPS
    True
    Donor 11
    GSM252454
    LPS Low 2 hrs Donor 8
    Low LPS
    True
    Donor 8
    GSM252455
    Anti-Trem1/LPS 2 hrs Donor 4
    aTREM1+LPS
    True
    Donor 4
    GSM252456
    Anti-Trem1/LPS 2 hrs Donor 9
    aTREM1+LPS
    True
    Donor 9
    GSM252457
    Anti-Trem1/LPS 2 hrs Donor 7
    aTREM1+LPS
    True
    Donor 7
    GSM252458
    Anti-Trem1/LPS 2 hrs Donor 5
    aTREM1+LPS
    True
    Donor 5
    GSM252459
    Anti-Trem1/LPS 2 hrs Donor 11
    aTREM1+LPS
    True
    Donor 11
    GSM252460
    Anti-Trem1/LPS 2 hrs Donor 6
    aTREM1+LPS
    True
    Donor 6
    GSM252461
    Anti-Trem1/LPS 2 hrs Donor 3
    aTREM1+LPS
    True
    Donor 3
    GSM252462
    Anti-Trem1/LPS 2 hrs Donor 10
    aTREM1+LPS
    True
    Donor 10
    GSM252463
    Anti-Trem1/LPS 2 hrs Donor 2
    aTREM1+LPS
    True
    Donor 2
    GSM252464
    Anti-Trem1/LPS 2 hrs Donor 1
    aTREM1+LPS
    True
    Donor 1
    GSM252465
    Control 2 hrs Donor 6
    Control
    True
    Donor 6
    GSM252466
    Control 2 hrs Donor 2
    Control
    True
    Donor 2
    GSM252467
    Control 2 hrs Donor 11
    Control
    True
    Donor 11
    GSM252468
    Control 2 hrs Donor 9
    Control
    True
    Donor 9
    GSM252469
    Control 2 hrs Donor 3
    Control
    True
    Donor 3
    GSM252470
    Control 2 hrs Donor 10
    Control
    True
    Donor 10
    GSM252471
    Control 2 hrs Donor 5
    Control
    True
    Donor 5
    GSM252472
    Control 2 hrs Donor 1
    Control
    True
    Donor 1
    GSM252473
    Control 2 hrs Donor 8
    Control
    True
    Donor 8
    GSM252474
    Control 2 hrs Donor 7
    Control
    True
    Donor 7
    GSM252475
    Control 2 hrs Donor 4
    Control
    True
    Donor 4
    GSM252476
    Vehicle 2 hrs Donor 11
    Vehicle
    True
    Donor 11
    GSM252477
    Vehicle 2 hrs Donor 8
    Vehicle
    True
    Donor 8
    GSM252478
    Vehicle 2 hrs Donor 6
    Vehicle
    True
    Donor 6
    GSM252479
    Vehicle 2 hrs Donor 4
    Vehicle
    True
    Donor 4
    GSM252480
    Vehicle 2 hrs Donor 3
    Vehicle
    True
    Donor 3
    GSM252481
    Vehicle 2 hrs Donor 2
    Vehicle
    True
    Donor 2
    GSM252482
    Vehicle 2 hrs Donor 5
    Vehicle
    True
    Donor 5
    GSM252483
    Vehicle 2 hrs Donor 7
    Vehicle
    True
    Donor 7
    GSM252484
    Vehicle 2 hrs Donor 9
    Vehicle
    True
    Donor 9
    GSM252485
    Vehicle 2 hrs Donor 1
    Vehicle
    True
    Donor 1

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