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SIDRA

GXB

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Description

cMyb and vMyb in human monocytes-GSE2816

Purpose

The transcriptional activities of c-Myb and its oncogenic variant v-Myb were compared by expressing them in primary human monocytes using recombinant adenovirus vectors. All the samples were compared to cells infected with a control adenovirus expressing only GFP. The results showed that v-Myb, which differs from c-Myb only by N- and C-terminal deletions and eleven amino acid substitutions, has a qualitatively different transcriptional activity.

Experimental Design

2 replicates of each type were analyzed. Replicates were performed independently, more than a week apart.

Additional Information
  • Liu F, Lei W, O'Rourke JP, Ness SA. Oncogenic mutations cause dramatic, qualitative changes in the transcriptional activity of c-Myb. Oncogene 2006 Feb 2;25(5):795-805. PMID: 16205643
  • Platform Affymetrix HG-U133_Plus_2
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    sampleset4000111_sampleannotations.csv

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