You are not logged in. | Log in

SIDRA

GXB

Clear Search
Updating...
Gene Symbol: --
Signal: --
Sample ID: --
Full Name--
Summary--
Links
Pubmed Articles --
User Notes --
Description

Gene expression profiling in pediatric meningococcal sepsis reveals dynamic changes in NK-cell and cytotoxic molecules-GSE11755

Purpose

Meningococcal sepsis remains an important cause of childhood morbidity and mortality. Largely due to logistic complexities of research in young children with acute life-threatening disease, very little is known regarding differential expression kinetics and molecular regulation of immune response genes in leukocyte subsets.

Experimental Design

In this prospective case-control study, six children with meningococcal sepsis were included. Blood was drawn at four time points (t=0, t=8, t=24 and t=72 h after admission to the paediatric intensive care unit). Blood was also collected from matched controls. Detailed immunophenotyping of leukocytes was performed; RNA isolated from whole blood, lymphocytes, monocytes, and granulocytes was used to perform Affymetrix micro-array gene expression analysis.No replicates were performed.Table 4. Results of between-subject analyses.Source Time (h) ca co/ca at t=TBlood t0: ca:2 3, co: a b c; t8: 2; t24 :ca:1 2 3; t72: ca:1 2.Lym t0: ca:2 3, co:a b c d;t8: ca:1 3 4;t24: ca:1 2 3 4 6; t72: ca: 1 2.Mono t0:ca: 1 3 4 6, co: a b d; t8: ca:1 2 3; t24:ca: 1 2 3; t72: ca:1.Numbers represent the patient identification numbers.Characters represent the individual controls.

Methods

In this prospective case-control study, six children with meningococcal sepsis were included. Blood was drawn at four time points (t=0, t=8, t=24 and t=72 h after admission to the paediatric intensive care unit). Blood was also collected from matched controls. Detailed immunophenotyping of leukocytes was performed; RNA isolated from whole blood, lymphocytes, monocytes, and granulocytes was used to perform Affymetrix micro-array gene expression analysis.

Platform Affymetrix HG-U133_Plus_2
No information available.
Default files:

Signal Data File

Download Annotations for Group Set:
Download Annotations for Group:
Download Ranklist:
Additional Files:

(Uploaded through the Files tab in the Annotation Tool)

sampleset4000035_sampleannotations.csv

Your email has been sent!
Advanced
Yes No
Yes No
X-axis Y-axis Both None
Yes No
Rank Lists
Group Set
Sort By
      Bar Plot Box Plot
    Overlays
      Updating...
      Your bug report has been sent!
      Sample Set Level   Dataset Level   Gene Level
      Your note has been added
      Loading...