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PGE2-induced OSM expression-GSE36995

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Description

PGE2-induced OSM expression-GSE36995
Purpose

The objective of the study was to compare the wound macs with corresponding macs derived from peripheral blood monocytes (MDMs). Wound site macrophage (wound macs were isolated from human subjects with chronic wounds. Matching blood monocyte derived macrophages (MDM) were obtained from same subjects. Transcriptome profiling (GeneChip, Affymetrix) was performed.The expression values of genes were normalized using global scaling approach.
Experimental Design

Blood monocyte derived macrophages or human wound macrophages were isolated and transcriptome analysis was performed using affymetrix gene chip analysis.
Additional Information
  • Ganesh K, Das A, Dickerson R, Khanna S et al. Prostaglandin E? induces oncostatin M expression in human chronic wound macrophages through Axl receptor tyrosine kinase pathway. J Immunol 2012 Sep 1;189(5):2563-73. PMID: 22844123
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    Platform Affymetrix HG-U133_Plus_2
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