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SIDRA

GXB

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Description

Gene expression profile of human monocytes stimulated with all-trans retinoic acid (ATRA) or 1,25a-dihydroxyvitamin D3 (1,25D3)-GSE46268

Purpose

A role for vitamin A in host defense against Mycobacterium tuberculosis has been suggested through epidemiological and in vitro studies; however, the antimicrobial mechanism is unclear. Here, we demonstrate that vitamin A mediates host defense through regulation of cellular cholesterol content.

Experimental Design

Monocytes derived from four independent healthy blood donors that were stimulated with control (CTRL), ATRA or 1,25D3 at 10-8M for 18 hours.

Additional Information
  • Wheelwright M, Kim EW, Inkeles MS, De Leon A et al. All-trans retinoic acid-triggered antimicrobial activity against Mycobacterium tuberculosis is dependent on NPC2. J Immunol 2014 Mar 1;192(5):2280-90. PMID: 24501203
  • Platform Affymetrix HG-U133_Plus_2
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