Genome-wide analysis of monocytes and T cells' response to interferon beta-GSE34627

To characterized the IFN-? transcriptional response in monocytes, a small but influential cell-subset, using gene expression profile and pathway analysis.

The unique expression profile of monocytes in response to Interferon-beta (IFN-?) might be masked by the response profile of the more abundant T cells.

Monocytes and T lymphocytes were isolated from 3 healthy volunteers. For each sample the expression profile of untreated cells was compared to the profile of IFN-? treated cells, i.e. 4 samples from each donor (2 cell types, with and without treatment), 12 samples total.