Leukotriene D4 induces gene expression in human monocytes through cysteinyl leukotriene type I receptor-GSE7807

To determine the gene expression signature of human monocytes in response to cysLTs and to elucidate the signaling pathways involved in monocyte activation.

4 control sample, 4 LTD4 stimulated samples

Gene expression was analyzed using oligonucleotide microarrays. Responsiveness to cysLTs was assessed by real-time PCR, calcium flux, kinase activation and chemotaxis assays.