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SIDRA

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Description

Leukotriene D4 induces gene expression in human monocytes through cysteinyl leukotriene type I receptor-GSE7807

Purpose

To determine the gene expression signature of human monocytes in response to cysLTs and to elucidate the signaling pathways involved in monocyte activation.

Experimental Design

4 control sample, 4 LTD4 stimulated samples

Methods

Gene expression was analyzed using oligonucleotide microarrays. Responsiveness to cysLTs was assessed by real-time PCR, calcium flux, kinase activation and chemotaxis assays.

Additional Information
  • Woszczek G, Chen LY, Nagineni S, Kern S et al. Leukotriene D(4) induces gene expression in human monocytes through cysteinyl leukotriene type I receptor.J Allergy Clin Immunol 2008 Jan;121(1):215-221.e1. PMID: 18028998
  • Platform Affymetrix HG-U133_Plus_2
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