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SIDRA

GXB

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Description

Subpopulations of CD163 positive macrophages are classically activated in psoriasis-GSE18686

Purpose

To determine the transcriptional profile associated with macrophage polarization to M1 or M2, we cultured macrophages derived from monocytes for 7 days and treated them with IFNg, IL-4, TNF, LPS, and LPS+IFNg (n=7). Psoriasis lesional and non-lesional skin biopsies were included (n=5 pairs).

Experimental Design

Comparison of the transcriptome of psoriasis with cytokine-treated macrophages.

Additional Information
  • Fuentes-Duculan J, Suárez-Fariñas M, Zaba LC, Nograles KE et al. A subpopulation of CD163-positive macrophages is classically activated in psoriasis. J Invest Dermatol 2010 Oct;130(10):2412-22. PMID: 20555352
  • Platform Illumina HumanHT-12 v3
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