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SIDRA

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Description

Expression data from human macrophages -GSE16385

Experimental Design

Human CD14 positive monocytes were purified from healthy volunteers’ blood and cultured in vitro for 4, 12, 24, 72 hours. While culturing, macrophages were activated alternatively with interleukin-4 (IL-4 100 ng/ml) or classically with interferon-gamma (IFNg 100 ng/ml)+tumor necrosis factor (TNF 50 ng/ml) or left without activation. Simultaneously, macrophages were also treated with vehicle (DMSO:ethanol) or 1mM synthetic PPARg agonist, Rosiglitazone. We used Affymetrix microarrays (U133Plus 2.0) to analyze activation and PPARg-induced gene expression changes.

Additional Information
  • Szanto A, Balint BL, Nagy ZS, Barta E et al. STAT6 transcription factor is a facilitator of the nuclear receptor PPAR?-regulated gene expression in macrophages and dendritic cells. Immunity 2010 Nov 24;33(5):699-712. PMID: 21093321
  • Platform Affymetrix HG-U133_Plus_2
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