GXB: Longitudinal comparison of monocytes from an HIV viremic vs avirmeic state-GSE5220

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Longitudinal comparison of monocytes from an HIV viremic vs avirmeic state-GSE5220

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Description	Longitudinal comparison of monocytes from an HIV viremic vs avirmeic state-GSE5220
Purpose	Longitudinal analysis of monocyte gene expressions patterns before and after cessation of HAART: understanding the impact of HIV viremia on the monocyte tranascritome.
Experimental Design	A longitudinal study was performed on 8 HIV infected individuals looking at gene expression changes in monocytes as a result of rebound of HIV viral load following termination of HAART: 8 patients pre and post HAART cessation.
Methods	We used microarrays to detail the global program of gene expression underlying defects in monocytes from HIV infected patients during viremia.
Additional Information	Tilton JC, Johnson AJ, Luskin MR, Manion MM et al. Diminished production of monocyte proinflammatory cytokines during human immunodeficiency virus viremia is mediated by type I interferons. J Virol 2006 Dec;80(23):11486-97. PMID: 17005663
Platform	Affymetrix HG-U133A

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