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SIDRA

GXB

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Description

Bacillus anthracis' lethal toxin induces broad transcriptional responses in human peripheral monocyte-GSE34407

Purpose

Anthrax lethal toxin directly targets human peripheral monocytes and causes multiple aberrant gene responses that would be expected to result in defects in human monocyte’s normal signaling transduction pathways and nction. This study provides further insights into the mechanisms associated with the host immune system collapse during an anthrax infection, and suggests that anthrax LT may have additional targets outside the well-known MAPK pathway.

Experimental Design

There were 4 replicates, 1 control and 1 toxin treated from 4 donors, with 8 samples total.

Additional Information
  • Chauncey KM, Lopez MC, Sidhu G, Szarowicz SE et al. Bacillus anthracis' lethal toxin induces broad transcriptional responses in human peripheral monocytes.BMC Immunol 2012 Jul 2;13:33. PMID: 22747600
  • Platform Affymetrix HG-U133_Plus_2
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