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SIDRA

GXB

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Description

Microarray analysis of human monocytes infected with Francisella tularensis-GSE12108

Purpose

The goal was to examine genomewide transcriptional reponses to these two strains, and identify differentially-regulated genes that may help explain the virulence of Schu S4.

Experimental Design

Human monocytes were infected with the Schu S4 isolate of Francisella tularensis tularensis (n=4), with F. tularensis subspecies novicida isolate U112 (n=4) or were left uninfected (n=6). Gene expression values were calculated using the gcrma package in R and BioConductor, and limma to identify differentially expressed genes. Submitted here are expression values calculated using R 2.7.1 and BioConductor 2.2 (FreeBSD/amd64) but the original were done using R 2.6.1 and BioConductor 2.1 (FreeBSD/amd64). Twelve other chips were pooled with these 14 for preprocessing.

Additional Information
  • Butchar JP, Cremer TJ, Clay CD, Gavrilin MA et al. Microarray analysis of human monocytes infected with Francisella tularensis identifies new targets of host response subversion. PLoS One 2008 Aug 13;3(8):e2924. PMID: 18698339
  • Platform Affymetrix HG-U133_Plus_2
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