Genome Wide Gene Expression Study of Circulating Monocytes in human with extremely high vs. low bone mass-GSE7158

To search for genes functionally important for osteoclastogenesis

We first recruited 878 healthy Chinese females aged 20-45 y with an average of 27.3 y when PBM is attainted and maintained. Then, we distributed the total sample according to the hip Z-score of PBM. From the bottom 100 and top 100 subjects of the PBM phenotypic distribution, we selected 12 subjects (Low-PBM 1-12) and 14 (High-PBM 1-14) with extremely low and high PBM for further DNA microarray experiments.Total RNA was extracted from monocytes

Lei S, Deng H