Human blood monocyte response to IL-17A in culture-GSE54884
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| Description | Human blood monocyte response to IL-17A in culture |
| Purpose | The levels of IL-17 are elevated in the serum of psoriasis patients. However, the effects of IL-17 on circulating leukocytes bearing the IL-17 receptors are not fully understood. Of particular interest are monocytes, as the activation and recruitment of effector monocytes underlies the pathobiology of a number systemic inflammatory diseases, including psoriasis co-morbidities, such as atherosclerosis, metabolic regulation in adipose tissue and psoriatic arthritis. Human monocytes highly express both IL-17RA and IL-17RC and chemotraffick in response to IL-17. We explored the impact of IL-17 on blood monocytes. Using cDNA microarray, we molecularly characterized how human blood monocytes respond to IL-17A in vitro. |
| Experimental Design | Total RNA was extratced from CD14+ monocytes (isolated from human blood) after 24hr culture with or without IL-17A (200ng/mL) |
| Additional Information | Suárez-Fariñas M, Wang CQ, Nograles KE, Krueger JG |
| Platform | Affymetrix HG-U133A |
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