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SIDRA

GXB

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Description

Analysis of blood myelomonocytic cells from RCC patients-GSE38424

Purpose

Myelomonocytic cells (i.e., monocytes or macrophages) play a key role in tumor progression as revealed by numerous mice tumor model studies. However, their contribution in human tumor progression is not well-studied. Using Renal Cell Carcinoma (RCC) as a model for human cancer, we performed a transcriptomal profiling of blood monocytes from RCC patients to investigate the contribution of these cells in cancer progression.

Experimental Design

Blood monocytes from RCC patients (with early or metastatic disease) or healthy donors (controls) were isolated, and then differential gene expression was detected with Limma.

Additional Information
  • Chittezhath M, Dhillon MK, Lim JY, Laoui D et al. Molecular profiling reveals a tumor-promoting phenotype of monocytes and macrophages in human cancer progression. Immunity 2014 Nov 20;41(5):815-29. PMID: 25453823
  • Platform Illumina HumanHT-12 v4
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